RT Journal Article
T1 Targeting Cancer Stem Cells to Overcome Therapy Resistance in Ovarian Cancer
A1 Muñoz-Galván, Sandra
A1 Carnero, Amancio
K1 Ovarian cancer
K1 Cancer stem cells
K1 Therapy resistance
K1 Neoplasias ováricas
K1 Células madre neoplásicas
K1 Resistencia a antineoplásicos
AB Ovarian cancer is the most lethal gynecological malignancy due to its late detection and high recurrence rate. Resistance to conventional platinum-based therapies and metastasis are attributed to a population of cells within tumors called cancer stem cells, which possess stem-like features and are able to recapitulate new tumors. Recent studies have deepened the understanding of the biology of ovarian cancer stem cells and their special properties and have identified multiple markers and signaling pathways responsible for their self-renewal abilities. Targeting cancer stem cells represents the most promising strategy for overcoming therapy resistance and reducing mortality in ovarian cancer, but further efforts must be made to improve our understanding of the mechanisms involved in therapy resistance. In this review, we summarize our current knowledge about ovarian cancer stem cells, their involvement in metastasis and their interactions with the tumor microenvironment; we also discuss the therapeutic approaches that are being developed to target them to prevent tumor relapse.
PB MDPI
YR 2020
FD 2020-06-04
LK http://hdl.handle.net/10668/3647
UL http://hdl.handle.net/10668/3647
LA en
NO Muñoz-Galván S, Carnero A. Targeting Cancer Stem Cells to Overcome Therapy Resistance in Ovarian Cancer. Cells. 2020 Jun 4;9(6):1402
DS RISalud
RD Apr 12, 2025