RT Journal Article
T1 Neural correlates of alerting and orienting impairment in multiple sclerosis patients.
A1 Vázquez-Marrufo, Manuel
A1 Galvao-Carmona, Alejandro
A1 González-Rosa, Javier J
A1 Hidalgo-Muñoz, Antonio R
A1 Borges, Mónica
A1 Ruiz-Peña, Juan Luis
A1 Izquierdo, Guillermo
K1 Potenciales evocados
K1 Esclerosis múltiple
K1 Pruebas neuropsicológicas
K1 Orientación
K1 Recurrencia
AB BACKGROUNDA considerable percentage of multiple sclerosis patients have attentional impairment, but understanding its neurophysiological basis remains a challenge. The Attention Network Test allows 3 attentional networks to be studied. Previous behavioural studies using this test have shown that the alerting network is impaired in multiple sclerosis. The aim of this study was to identify neurophysiological indexes of the attention impairment in relapsing-remitting multiple sclerosis patients using this test.RESULTSAfter general slowing had been removed in patients group to isolate the effects of each condition, some behavioral differences between them were obtained. About Contingent Negative Variation, a statistically significant decrement were found in the amplitude for Central and Spatial Cue Conditions for patient group (p<0.05). ANOVAs showed for the patient group a significant latency delay for P1 and N1 components (p<0.05) and a decrease of P3 amplitude for congruent and incongruent stimuli (p<0.01). With regard to correlation analysis, PASAT-3s and SDMT showed significant correlations with behavioral measures of the Attention Network Test (p<0.01) and an ERP parameter (CNV amplitude).CONCLUSIONSBehavioral data are highly correlated with the neuropsychological scores and show that the alerting and orienting mechanisms in the patient group were impaired. Reduced amplitude for the Contingent Negative Variation in the patient group suggests that this component could be a physiological marker related to the alerting and orienting impairment in relapsing-remitting multiple sclerosis. P1 and N1 delayed latencies are evidence of the demyelination process that causes impairment in the first steps of the visual sensory processing. Lastly, P3 amplitude shows a general decrease for the pathological group probably indexing a more central impairment. These results suggest that the Attention Network Test give evidence of multiple levels of attention impairment, which could help in the assessment and treatment of relapsing-remitting multiple sclerosis patients.
PB Public Library of Science
YR 2014
FD 2014-05-12
LK http://hdl.handle.net/10668/2158
UL http://hdl.handle.net/10668/2158
LA en
NO Vázquez-Marrufo M, Galvao-Carmona A, González-Rosa JJ, Hidalgo-Muñoz AR, Borges M, Ruiz-Peña JL, et al. Neural correlates of alerting and orienting impairment in multiple sclerosis patients. PLoS ONE. 2014; 9(5):e97226
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 6, 2025