RT Journal Article
T1 Ulcerative colitis: Gut microbiota, immunopathogenesis and application of natural products in animal models.
A1 Nascimento, Roberto de Paula do
A1 Machado, Ana Paula da Fonseca
A1 Galvez, Julio
A1 Cazarin, Cinthia Baú Betim
A1 Maróstica Junior, Mario Roberto
K1 Bioactive compounds
K1 Dextran sodium sulfate
K1 Functional foods
K1 Inflammation
K1 Inflammatory bowel diseases
K1 Microbiota
K1 Natural products
K1 Oxazolone
K1 Trinitrobenzene sulfonic acid
AB Ulcerative colitis (UC) is an inflammatory bowel disease with increasing incidence in the world, especially in developing countries. Although knowledge of its pathogenesis has progressed over the last years, some details require clarification. Studies have highlighted the role of microbial dysbiosis and immune dysfunction as essential factors that may initiate the typical high-grade inflammatory outcome. In order to better understand the immunopathophysiological aspects of UC, experimental murine models are valuable tools. Some of the most commonly used chemicals to induce colitis are trinitrobenzene sulfonic acid, oxazolone and dextran sodium sulfate. These may also be used to investigate new ways of preventing or treating UC and therefore improving targeting in human studies. The use of functional foods or bioactive compounds from plants may constitute an innovative direction towards the future of alternative medicine. Considering the above, this review focused on updated information regarding the 1. gut microbiota and immunopathogenesis of UC; 2. the most utilized animal models of the disease and their relevance; and 3. experimental application of natural products, not yet tested in clinical trials.
YR 2020
FD 2020-07-25
LK http://hdl.handle.net/10668/16005
UL http://hdl.handle.net/10668/16005
LA en
NO Nascimento RPD, Machado APDF, Galvez J, Cazarin CBB, Maróstica Junior MR. Ulcerative colitis: Gut microbiota, immunopathogenesis and application of natural products in animal models. Life Sci. 2020 Oct 1;258:118129.
DS RISalud
RD Apr 5, 2025