RT Journal Article
T1 Inverse relation between levels of anti-oxidized-LDL antibodies and eicosapentanoic acid (EPA).
A1 Garrido-Sánchez, Lourdes
A1 García-Fuentes, E
A1 Rojo-Martínez, Gemma
A1 Cardona, Fernando
A1 Soriguer, Federico
A1 Tinahones Madueño, Francisco José
K1 oxidized low density lipoprotein
K1 Antibodies
K1 Atherosclerosis
K1 Anticuerpos
K1 Aterosclerosis
K1 Factores de edad
K1 Autoanticuerpos
K1 Ácido Eicosapentaenoico
K1 Ácidos Grasos
K1 Ácidos Grasos Insaturados
K1 Lipoproteínas LDL
K1 Fosfolípidos
K1 Análisis de Regresión
K1 Oxidized LDL
K1 Antibodies
K1 Fatty acids
AB Oxidative modification of LDL is thought to play an important role in the development of atherosclerosis. Susceptibility of LDL to peroxidation may partly depend on the compositional characteristics of the antioxidant and fatty acid content. The aim of this study was to examine the association between levels of antibodies to oxidized LDL and the various serum fatty acids in women. A total of 465 women aged 18-65 years were selected randomly from the adult population census of Pizarra, a town in southern Spain. Measurement of anti-oxidized-LDL was done by ELISA and the fatty acid composition of serum phospholipids was determined by GC. The levels of anti-oxidized-LDL antibodies were significantly related with age (r - 0.341, P < 0.001), BMI (r - 0.239, P < 0.001), waist:hip ratio (r - 0.285, P < 0.001), glucose (r - 0.208, P < 0.001), cholesterol (r - 0.243, P < 0.001), LDL-cholesterol (r - 0.185, P = 0.002), EPA (r - 0.159, P = 0.003), DHA (r - 0.121, P = 0.026), and the sum of the serum phospholipid n-3 PUFA (r - 0.141, P = 0.009). Multiple regression analysis showed that the variables that explained the behaviour of the levels of anti-oxidized-LDL antibodies were age (P < 0.001) and the serum phospholipid EPA (P < 0.001). This study showed that the fatty acid composition of serum phospholipids, and especially the percentage of EPA, was inversely related with the levels of anti-oxidized-LDL antibodies.
PB Cambridge University Press
SN 0007-1145
YR 2008
FD 2008-02-06
LK http://hdl.handle.net/10668/622
UL http://hdl.handle.net/10668/622
LA en
NO Garrido-Sánchez L, García-Fuentes E, Rojo-Martínez G, Cardona F, Soriguer F, Tinahones Madueño FJ. Inverse relation between levels of anti-oxidized-LDL antibodies and eicosapentanoic acid (EPA). Br. J. Nutr. 2008;100(3):585-9
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 5, 2025