RT Journal Article
T1 The uprise of RNA biology in neuroendocrine neoplasms: altered splicing and RNA species unveil translational opportunities.
A1 Blazquez-Encinas, Ricardo
A1 Moreno-Montilla, Maria Trinidad
A1 Garcia-Vioque, Victor
A1 Gracia-Navarro, Francisco
A1 Alors-Perez, Emilia
A1 Pedraza-Arevalo, Sergio
A1 Ibañez-Costa, Alejandro
A1 Castaño, Justo P
K1 Long non-coding RNAs
K1 Neuroendocrine neoplasms
K1 RNA
K1 Splicing
K1 MicroRNAs
AB Neuroendocrine neoplasms (NENs) comprise a highly heterogeneous group of tumors arising from the diffuse neuroendocrine system. NENs mainly originate in gastrointestinal, pancreatic, and pulmonary tissues, and despite being rare, show rising incidence. The molecular mechanisms underlying NEN development are still poorly understood, although recent studies are unveiling their genomic, epigenomic and transcriptomic landscapes. RNA was originally considered as an intermediary between DNA and protein. Today, compelling evidence underscores the regulatory relevance of RNA processing, while new RNA molecules emerge with key functional roles in core cell processes. Indeed, correct functioning of the interrelated complementary processes comprising RNA biology, its processing, transport, and surveillance, is essential to ensure adequate cell homeostasis, and its misfunction is related to cancer at multiple levels. This review is focused on the dysregulation of RNA biology in NENs. In particular, we survey alterations in the splicing process and available information implicating the main RNA species and processes in NENs pathology, including their role as biomarkers, and their functionality and targetability. Understanding how NENs precisely (mis)behave requires a profound knowledge at every layer of their heterogeneity, to help improve NEN management. RNA biology provides a wide spectrum of previously unexplored processes and molecules that open new avenues for NEN detection, classification and treatment. The current molecular biology era is rapidly evolving to facilitate a detailed comprehension of cancer biology and is enabling the arrival of personalized, predictive and precision medicine to rare tumors like NENs.
PB Springer
YR 2022
FD 2022-11-15
LK http://hdl.handle.net/10668/20731
UL http://hdl.handle.net/10668/20731
LA en
NO Blázquez-Encinas R, Moreno-Montilla MT, García-Vioque V, Gracia-Navarro F, Alors-Pérez E, Pedraza-Arevalo S, et al. The uprise of RNA biology in neuroendocrine neoplasms: altered splicing and RNA species unveil translational opportunities. Rev Endocr Metab Disord. 2023 Apr;24(2):267-282
NO This work has been supported by Spanish Ministry of Economy [MINECO; BFU2016–80360-R (to JPC)] and Ministry of Science and Innovation [MICINN; PID2019‐105201RB‐I00, AEI/https://doi.org/10.13039/501100011033 (to JPC)]. Instituto de Salud Carlos III, co‐funded by European Union (ERDF/ESF, “Investing in your future”) [Postdoctoral Grant Sara Borrell CD19/00255 (toAIC); Predoctoral contract FI17/00282 (to EAP)]. Society for Endocrinology Early Career Grant (to AIC). Spanish Ministry of Universities Predoctoral contracts FPU18/02275 (to R.B-E.) and FPU20/03958 (to V.G.V). Junta de Andalucía (BIO‐0139); FEDER UCO202099901918904 (to JPC and AIC). Grupo Español de Tumores Neuroendocrinos y Endocrinos (GETNE2016 and GETNE2019 Research grants, to JPC). Fundación Eugenio Rodríguez Pascual (FERP2020Grant to JPC). CIBERobn Fisiopatología de la Obesidad y Nutrición.CIBER is an initiative of Instituto de Salud Carlos III
DS RISalud
RD Apr 10, 2025