RT Journal Article
T1 Bone Mineral Density and Serum Levels of Soluble Tumor Necrosis Factors, Estradiol, and Osteoprotegerin in Postmenopausal Women with Cirrhosis after Viral Hepatitis
A1 Gonzalez-Calvin, Jorge L
A1 Mundi, Jose L
A1 Casado-Caballero, Francisco J
A1 Abadia, Ana C
A1 Martin-Ibanez, Jose J
K1 Absorciometría de Fotón
K1 Aminoácidos
K1 Densidad Ósea
K1 Huesos
K1 Estudios Transversales
K1 Estradiol
K1 Hepatitis Viral Humana
K1 Cirrosis Hepática
K1 Mediana Edad
K1 Osteoprotegerina
K1 Posmenopausia
K1 Receptor Activator of Nuclear Factor-kappa B
K1 Receptores del Factor de Necrosis Tumoral
K1 Factores de Riesgo
K1 Factores de Necrosis Tumoral
K1 Anciano de 80 o más Años
K1 Anciano
K1 Femenina
K1 Humanos
AB CONTEXT: Cirrhosis after viral hepatitis has been identified as a risk factor for osteoporosis in men. However, in postmenopausal women, most studies have evaluated the effect of primary biliary cirrhosis, but little is known about the effect of viral cirrhosis on bone mass [bone mineral density (BMD)] and bone metabolism.OBJECTIVE: Our objective was to assess the effect of viral cirrhosis on BMD and bone metabolism in postmenopausal women.DESIGN: We conducted a cross-sectional descriptive study.SETTING AND PATIENTS: We studied 84 postmenopausal female outpatients with viral cirrhosis and 96 healthy postmenopausal women from the general community. BMD was measured by dual-energy x-ray absorptiometry at lumbar spine (LS) and femoral neck (FN).RESULTS: The percentage with osteoporosis did not significantly differ between patients (LS, 43.1%; FN, 32.2%) and controls (LS, 41.2%; FN, 29.4%), and there was no difference in BMD (z-score) between groups. Serum concentrations of soluble TNF receptors, estradiol, and osteoprotegerin (OPG) were significantly higher in patients vs. controls (P < 0.001, P < 0.05, and P < 0.05, respectively). No significant difference was observed in urinary deoxypyridinoline. Serum OPG levels were positively correlated with soluble TNF receptors (r = 0.35; P < 0.02) and deoxypyridinoline (r = 0.37; P < 0.05).CONCLUSIONS: This study shows that bone mass and bone resorption rates do not differ between postmenopausal women with viral cirrhosis and healthy postmenopausal controls and suggests that viral cirrhosis does not appear to increase the risk of osteoporosis in these women. High serum estradiol and OPG concentrations may contribute to preventing the bone loss associated with viral cirrhosis in postmenopausal women.
PB Endocrine Society
SN 0021-972X
YR 2009
FD 2009-12
LK http://hdl.handle.net/10668/470
UL http://hdl.handle.net/10668/470
LA en
NO González-Calvin JL, Mundi JL, Casado-Caballero FJ, Abadia AC, Martin-Ibañez JJ. Bone mineral density and serum levels of soluble tumor necrosis factors, estradiol, and osteoprotegerin in postmenopausal women with cirrhosis after viral hepatitis. J Clin Endocrinol Metab. 2009 Dec;94(12):4844-50
DS RISalud
RD Apr 11, 2025