RT Journal Article
T1 Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels.
A1 Tinahones, Francisco José
A1 Coín-Aragüez, Leticia
A1 Mayas, María Dolores
A1 García-Fuentes, Eduardo
A1 Hurtado-Del-Pozo, Carmen
A1 Vendrell, Joan
A1 Cardona, Fernando
A1 Calvo, Rosa-María
A1 Obregón, María-Jesus
A1 El Bekay, Rajaa
K1 Inductores de la Angiogénesis
K1 Marcadores Biológicos
K1 Expresión Génica
K1 Humanos
K1 Resistencia a la Insulina
K1 Metaloproteasas
K1 Neovascularización Fisiológica
K1 Obesidad
K1 Obesidad Mórbida
K1 Epiplón
K1 Grasa Subcutánea
K1 Factor A de Crecimiento Endotelial Vascular
K1 Tejido Adiposo
AB BACKGROUNDThe expansion of adipose tissue is linked to the development of its vasculature, which appears to have the potential to regulate the onset of obesity. However, at present, there are no studies highlighting the relationship between human adipose tissue angiogenesis and obesity-associated insulin resistance (IR).RESULTSOur aim was to analyze and compare angiogenic factor expression levels in both subcutaneous (SC) and omentum (OM) adipose tissues from morbidly obese patients (n = 26) with low (OB/L-IR) (healthy obese) and high (OB/H-IR) degrees of IR, and lean controls (n = 17). Another objective was to examine angiogenic factor correlations with obesity and IR.Here we found that VEGF-A was the isoform with higher expression in both OM and SC adipose tissues, and was up-regulated 3-fold, together with MMP9 in OB/L-IR as compared to leans. This up-regulation decreased by 23% in OB/-H-IR compared to OB/L-IR. On the contrary, VEGF-B, VEGF-C and VEGF-D, together with MMP15 was down-regulated in both OB/H-IR and OB/L-IR compared to lean patients. Moreover, MMP9 correlated positively and VEGF-C, VEGF-D and MMP15 correlated negatively with HOMA-IR, in both SC and OM.CONCLUSIONWe hereby propose that the alteration in MMP15, VEGF-B, VEGF-C and VEGF-D gene expression may be caused by one of the relevant adipose tissue processes related to the development of IR, and the up-regulation of VEGF-A in adipose tissue could have a relationship with the prevention of this pathology.
PB BioMed Central
YR 2012
FD 2012-04
LK http://hdl.handle.net/10668/860
UL http://hdl.handle.net/10668/860
LA en
NO Tinahones FJ, Coín-Aragüez L, Mayas MD, García-Fuentes E, Hurtado-del-Pozo C, Vendrell J, et al. Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels. BMC Physiol. 2012; 12:4
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 6, 2025