TY - JOUR AU - Bendell, Johanna C. AU - Sauri, Tamara AU - Cubillo Gracian, Antonio AU - Alvarez, Rafael AU - Lopez-Lopez, Carlos AU - Garcia-Alfonso, Pilar AU - Hussein, Maen AU - Limon Miron, Maria-Luisa AU - Cervantes, Andres AU - Montagut, Clara AU - Santos Vivas, Cristina AU - Bessudo, Alberto AU - Plezia, Patricia AU - Moons, Veerle AU - Andel, Johannes AU - Bennouna, Jaafar AU - van der Westhuizen, Andre AU - Samuel, Leslie AU - Rossomanno, Simona AU - Boetsch, Christophe AU - Lahr, Angelika AU - Franjkovic, Izolda AU - Heil, Florian AU - Lechner, Katharina AU - Krieter, Oliver AU - Hurwitz, Herbert AU - McCAVE Study Grp PY - 2019 DO - 10.1634/theoncologist.2019-0291 SN - 1083-7159 UR - https://hdl.handle.net/10668/27428 T2 - Oncologist AB - Background Bevacizumab, a VEGF-A inhibitor, in combination with chemotherapy, has proven to increase progression-free survival (PFS) and overall survival in multiple lines of therapy of metastatic colorectal cancer (mCRC). The angiogenic factor... LA - en PB - Wiley KW - First-line metastatic colorectal cancer KW - Angiopoetin-2 KW - VEGF-A KW - Vanucizumab KW - Bevacizumab KW - Antitumor-activity KW - Clinical-outcomes KW - Phase-ii KW - Amg 386 KW - Angiopoietin-2 KW - Combination KW - Antibody KW - Hypertension KW - Oxaliplatin KW - Biomarker TI - The McCAVE Trial: Vanucizumab plus mFOLFOX-6 Versus Bevacizumab plus mFOLFOX-6 in Patients with Previously Untreated Metastatic Colorectal Carcinoma (mCRC) TY - research article VL - 25 ER -