RT Journal Article
T1 Diets based on virgin olive oil or fish oil but not on sunflower oil prevent age-related alveolar bone resorption by mitochondrial-related mechanisms.
A1 Bullón, Pedro
A1 Battino, Maurizio
A1 Varela-López, Alfonso
A1 Pérez-López, Patricia
A1 Granados-Principal, Sergio
A1 Ramírez-Tortosa, María C
A1 Ochoa, Julio J
A1 Cordero, Mario D
A1 González-Alonso, Adrián
A1 Ramírez-Tortosa, César L
A1 Rubini, Corrado
A1 Zizzi, Antonio
A1 Quiles, José L
K1 Aging
K1 Envejecimiento
K1 Alveolar Bone
K1 Hueso Alveolar
K1 Diet
K1 Dieta
K1 Fatty Acids
K1 Ácidos grasos
K1 Periodontitis
K1 Sunflower
K1 Girasol
K1 Vegetable Oils
K1 Aceites vegetales
K1 Animals
K1 Animales
K1 Resorción ósea
K1 Dietary Fats
K1 Grasas en la dieta
K1 Aceites de pescado
K1 Male
K1 Masculino
K1 Mitocondrias
K1 Aceites vegetales
K1 Rats
K1 Ratas
K1 Ratas Wistar
K1 Proceso alveolar
AB BACKGROUND/OBJECTIVESAging enhances frequency of chronic diseases like cardiovascular diseases or periodontitis. Here we reproduced an age-dependent model of the periodontium, a fully physiological approach to periodontal conditions, to evaluate the impact of dietary fat type on gingival tissue of young (6 months old) and old (24 months old) rats.METHODS/FINDINGSAnimals were fed life-long on diets based on monounsaturated fatty acids (MUFA) as virgin olive oil, n-6 polyunsaturated fatty acids (n-6PUFA), as sunflower oil, or n-3PUFA, as fish oil. Age-related alveolar bone loss was higher in n-6PUFA fed rats, probably as a consequence of the ablation of the cell capacity to adapt to aging. Gene expression analysis suggests that MUFA or n-3PUFA allowed mitochondria to maintain an adequate turnover through induction of biogenesis, autophagy and the antioxidant systems, and avoiding mitochondrial electron transport system alterations.CONCLUSIONSThe main finding is that the enhanced alveolar bone loss associated to age may be targeted by an appropriate dietary treatment. The mechanisms involved in this phenomenon are related with an ablation of the cell capacity to adapt to aging. Thus, MUFA or n-3PUFA might allow mitochondrial maintaining turnover through biogenesis or autophagy. They might also be able to induce the corresponding antioxidant systems to counteract age-related oxidative stress, and do not inhibit mitochondrial electron transport chain. From the nutritional and clinical point of view, it is noteworthy that the potential treatments to attenuate alveolar bone loss (a feature of periodontal disease) associated to age could be similar to some of the proposed for the prevention and treatment of cardiovascular diseases, a group of pathologies recently associated with age-related periodontitis.
PB Public Library of Science
YR 2013
FD 2013-09-16
LK http://hdl.handle.net/10668/1631
UL http://hdl.handle.net/10668/1631
LA en
NO Bullón P, Battino M, Varela-López A, Pérez-López P, Granados-Principal S, Ramírez-Tortosa MC, et al. Diets based on virgin olive oil or fish oil but not on sunflower oil prevent age-related alveolar bone resorption by mitochondrial-related mechanisms. PLoS ONE.2013; 8(9):e74234
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 6, 2025