RT Journal Article
T1 Immediate improvement of left ventricular mechanics following transcatheter aortic valve replacement.
A1 Lozano Granero, Vanesa Cristina
A1 Fernández Santos, Sara
A1 Fernández-Golfín, Covadonga
A1 Plaza Martín, María
A1 de la Hera Galarza, Jesús María
A1 Faletra, Francesco Fulvio
A1 Swaans, Martin J
A1 López-Fernández, Teresa
A1 Mesa, Dolores
A1 La Canna, Giovanni
A1 Echeverría García, Tomás
A1 Habib, Gilbert
A1 Martíne Monzonís, Amparo
A1 Zamorano Gómez, José Luis
K1 aortic stenosis
K1 echocardiography
K1 left ventricular mechanics
K1 strain
K1 transcatheter aortic valve replacement
AB Left ventricular (LV) mechanics are impaired in patients with severe aortic stenosis (AS). Transcatheter aortic valve replacement (TAVR) has become a widespread technique for patients with severe AS considered inoperable or high risk for traditional open-surgery. This procedure could have a positive impact in LV mechanics. The aim of this study was to evaluate the immediate effect of TAVR on LV function recovery, as assessed by myocardial deformation parameters. One-hundred twelve consecutive patients (81.4 ± 6.4 years, 50% female) from 10 centres in Europe with severe AS who successfully underwent TAVR with either a self-expanding CoreValve (Medtronic, Minneapolis, MN) or a mechanically expanded Lotus valve (Boston Scientific, Natick, MA) were enrolled in a prospective multi-center study. A complete echocardiographic examination was performed at baseline and immediately before discharge, including the assessment of LV strain using standard two-dimensional images. Echocardiographic examination with global longitudinal strain (GLS) quantification could be obtained in 92 patients, because of echocardiographic and logistic reasons. Between examinations, a modest statistically significant improvement in GLS could be seen (GLS% -15.00 ± 4.80 at baseline;-16.15 ± 4.97 at discharge, p = 0.028). In a stratified analysis, only women showed a significant improvement in GLS and a trend towards greater improvement in GLS according to severity of systolic dysfunction as measured by LV ejection fraction could be noted. Immediate improvement in GLS was appreciated after TAVR procedure. Whether this finding continues to be noted in a more prolonged follow-up and its clinical implications need to be assessed in further studies.
YR 2018
FD 2018-06-20
LK http://hdl.handle.net/10668/12619
UL http://hdl.handle.net/10668/12619
LA en
DS RISalud
RD Apr 6, 2025