RT Journal Article
T1 Cannabinoquinones: Synthesis and Biological Profile.
A1 Caprioglio, Diego
A1 Mattoteia, Daiana
A1 Taglialatela-Scafati, Orazio
A1 Muñoz, Eduardo
A1 Appendino, Giovanni
K1  Cannabinoids
K1 Immunomodulation
K1 Oxidation
K1 Quinones
K1 Scleroderma
K1 Thia-Michael addition
AB Neutral cannabinoids are oxidatively unstable and are converted into quinone derivatives by atmospheric- and/or chemical oxidative dearomatization. The study of cannabinoquinones has long been plagued by their lability toward additional oxidative degradation, but full substitution of the quinone ring, as well as the introduction of steric hindrance on the alkyl substituent, have provided sufficient stability for a systematic investigation of their bioactivity and for further clinical development. These studies culminated in the discovery of the aminocannabinoquinone VCE-004.8 (5), a compound under phase 2 clinical development with orphan drug status by EMA and FDA for the management of scleroderma. The synthesis and rich chemistry of these compounds will be described, summarizing their biological profile and clinical potential.
PB MDPI
YR 2021
FD 2021-07-02
LK http://hdl.handle.net/10668/18302
UL http://hdl.handle.net/10668/18302
LA en
NO Caprioglio D, Mattoteia D, Taglialatela-Scafati O, Muñoz E, Appendino G. Cannabinoquinones: Synthesis and Biological Profile. Biomolecules. 2021 Jul 5;11(7):991
DS RISalud
RD Apr 16, 2025