%0 Journal Article
%A Moreno-Grau, Sonia
%A Fernández, Maria Victoria
%A de Rojas, Itziar
%A Garcia-González, Pablo
%A Hernández, Isabel
%A Farias, Fabiana
%A Budde, John P
%A Quintela, Inés
%A Madrid, Laura
%A González-Pérez, Antonio
%A Montrreal, Laura
%A Alarcón-Martín, Emilio
%A Alegret, Montserrat
%A Maroñas, Olalla
%A Pineda, Juan Antonio
%A Macías, Juan
%A GR@ACE study group
%A DEGESCO consortium
%A Marquié, Marta
%A Valero, Sergi
%A Benaque, Alba
%A Clarimón, Jordi
%A Bullido, Maria Jesus
%A García-Ribas, Guillermo
%A Pástor, Pau
%A Sánchez-Juan, Pascual
%A Álvarez, Victoria
%A Piñol-Ripoll, Gerard
%A García-Alberca, Jose María
%A Royo, José Luis
%A Franco-Macías, Emilio
%A Mir, Pablo
%A Calero, Miguel
%A Medina, Miguel
%A Rábano, Alberto
%A Ávila, Jesús
%A Antúnez, Carmen
%A Real, Luis Miguel
%A Orellana, Adelina
%A Carracedo, Ángel
%A Sáez, María Eugenia
%A Tárraga, Lluís
%A Boada, Mercè
%A Cruchaga, Carlos
%A Ruiz, Agustín
%A Alzheimer’s Disease Neuroimaging Initiative
%T Long runs of homozygosity are associated with Alzheimer's disease.
%D 2021
%U https://hdl.handle.net/10668/25382
%X Long runs of homozygosity (ROH) are contiguous stretches of homozygous genotypes, which are a footprint of inbreeding and recessive inheritance. The presence of recessive loci is suggested for Alzheimer's disease (AD); however, their search has been poorly assessed to date. To investigate homozygosity in AD, here we performed a fine-scale ROH analysis using 10 independent cohorts of European ancestry (11,919 AD cases and 9181 controls.) We detected an increase of homozygosity in AD cases compared to controls [βAVROH (CI 95%) = 0.070 (0.037-0.104); P = 3.91 × 10-5; βFROH (CI95%) = 0.043 (0.009-0.076); P = 0.013]. ROHs increasing the risk of AD (OR > 1) were significantly overrepresented compared to ROHs increasing protection (p  1) were significantly overrepresented compared to ROHs increasing protection (p 
%~