TY - JOUR AU - Navas-Pérez, Enrique AU - Vicente-García, Cristina AU - Mirra, Serena AU - Burguera, Demian AU - Fernàndez-Castillo, Noèlia AU - Ferrán, José Luis AU - López-Mayorga, Macarena AU - Alaiz-Noya, Marta AU - Suárez-Pereira, Irene AU - Antón-Galindo, Ester AU - Ulloa, Fausto AU - Herrera-Úbeda, Carlos AU - Cuscó, Pol AU - Falcón-Moya, Rafael AU - Rodríguez-Moreno, Antonio AU - D'Aniello, Salvatore AU - Cormand, Bru AU - Marfany, Gemma AU - Soriano, Eduardo AU - Carrión, Ángel M. AU - Carvajal, Jaime J. AU - Garcia-Fernàndez, Jordi PY - 2020 DO - 10.1186/s13059-020-02172-3 UR - http://hdl.handle.net/10668/3788 T2 - Genome Biology AB - BackgroundOne of the most unusual sources of phylogenetically restricted genes is the molecular domestication of transposable elements into a host genome as functional genes. Although these kinds of events are sometimes at the core of key... LA - en PB - BioMed Central, Springer Nature KW - Genetic novelty KW - Transposon domestication KW - Bex3 KW - Tceal KW - Placental mammals KW - Gene cluster KW - Neurodevelopmental disorders KW - mTOR KW - Autism spectrum disorder KW - Euterios KW - Familia de multigenes KW - Trastornos del neurodesarrollo KW - Serina-treonina quinasas TOR KW - Trastorno del espectro autista KW - Medical Subject Headings::Organisms::Eukaryota::Animals KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::Apoptosis Regulatory Proteins KW - Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Mental Disorders Diagnosed in Childhood::Child Development Disorders, Pervasive::Autistic Disorder KW - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic::Gene Silencing::CRISPR-Cas Systems KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins KW - Medical Subject Headings::Phenomena and Processes::Biological Phenomena::Biological Processes::Biological Evolution::Evolution, Molecular KW - Medical Subject Headings::Check Tags::Female KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Laboratory::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred C57BL KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic::Mice, Knockout KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nerve Tissue Proteins KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phylogeny KW - Medical Subject Headings::Anatomy::Embryonic Structures::Placenta KW - Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::TOR Serine-Threonine Kinases KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Transcription Factors KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Interspersed Repetitive Sequences::DNA Transposable Elements KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Multigene Family TI - Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions TY - research article ER -