RT Journal Article
T1 A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study.
A1 Imamura, Fumiaki
A1 Sharp, Stephen J
A1 Koulman, Albert
A1 Schulze, Matthias B
A1 Kröger, Janine
A1 Griffin, Julian L
A1 Huerta, José M
A1 Guevara, Marcela
A1 Sluijs, Ivonne
A1 Agudo, Antonio
A1 Ardanaz, Eva
A1 Balkau, Beverley
A1 Boeing, Heiner
A1 Chajes, Veronique
A1 Dahm, Christina C
A1 Dow, Courtney
A1 Fagherazzi, Guy
A1 Feskens, Edith J M
A1 Franks, Paul W
A1 Gavrila, Diana
A1 Gunter, Marc
A1 Kaaks, Rudolf
A1 Key, Timothy J
A1 Khaw, Kay-Tee
A1 Kühn, Tilman
A1 Melander, Olle
A1 Molina-Portillo, Elena
A1 Nilsson, Peter M
A1 Olsen, Anja
A1 Overvad, Kim
A1 Palli, Domenico
A1 Panico, Salvatore
A1 Rolandsson, Olov
A1 Sieri, Sabina
A1 Sacerdote, Carlotta
A1 Slimani, Nadia
A1 Spijkerman, Annemieke M W
A1 Tjønneland, Anne
A1 Tumino, Rosario
A1 van der Schouw, Yvonne T
A1 Langenberg, Claudia
A1 Riboli, Elio
A1 Forouhi, Nita G
A1 Wareham, Nick J
AB Combinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated. We measured plasma phospholipid fatty acids by gas chromatography in 27,296 adults, including 12,132 incident cases of T2D, over the follow-up period between baseline (1991-1998) and 31 December 2007 in 8 European countries in EPIC-InterAct, a nested case-cohort study. The first principal component derived by principal component analysis of 27 individual fatty acids (mole percentage) was the main exposure (subsequently called the fatty acid pattern score [FA-pattern score]). The FA-pattern score was partly characterised by high concentrations of linoleic acid, stearic acid, odd-chain fatty acids, and very-long-chain saturated fatty acids and low concentrations of γ-linolenic acid, palmitic acid, and long-chain monounsaturated fatty acids, and it explained 16.1% of the overall variability of the 27 fatty acids. Based on country-specific Prentice-weighted Cox regression and random-effects meta-analysis, the FA-pattern score was associated with lower incident T2D. Comparing the top to the bottom fifth of the score, the hazard ratio of incident T2D was 0.23 (95% CI 0.19-0.29) adjusted for potential confounders and 0.37 (95% CI 0.27-0.50) further adjusted for metabolic risk factors. The association changed little after adjustment for individual fatty acids or fatty acid subclasses. In cross-sectional analyses relating the FA-pattern score to metabolic, genetic, and dietary factors, the FA-pattern score was inversely associated with adiposity, triglycerides, liver enzymes, C-reactive protein, a genetic score representing insulin resistance, and dietary intakes of soft drinks and alcohol and was positively associated with high-density-lipoprotein cholesterol and intakes of polyunsaturated fat, dietary fibre, and coffee (p  A combination of individual fatty acids, characterised by high concentrations of linoleic acid, odd-chain fatty acids, and very long-chain fatty acids, was associated with lower incidence of T2D. The specific fatty acid pattern may be influenced by metabolic, genetic, and dietary factors.
YR 2017
FD 2017-10-11
LK http://hdl.handle.net/10668/11666
UL http://hdl.handle.net/10668/11666
LA en
DS RISalud
RD Apr 5, 2025