RT Journal Article
T1 Serum sCD163 levels are associated with type 2 diabetes mellitus and are influenced by coffee and wine consumption: results of the Di@bet.es study.
A1 Rojo-Martínez, Gemma
A1 Maymó-Masip, Elsa
A1 Rodríguez, M Mar
A1 Solano, Esther
A1 Goday, Albert
A1 Soriguer, Federico
A1 Valdés, Sergio
A1 Chaves, Felipe Javier
A1 Delgado, Elías
A1 Colomo, Natalia
A1 Hernández, Pilar
A1 Vendrell, Joan
A1 Chacón, Matilde R
K1 Café
K1 Diabetes mellitus tipo II
K1 Conducta bebedora
K1 Hábitos alimenticios
K1 Funciones de verosimilitud
K1 Solubilidad
K1 Vino
K1 España
AB OBJECTIVESerum levels of soluble TNF-like weak inducer of apoptosis (sTWEAK) and its scavenger receptor CD163 (sCD163) have been linked to insulin resistance. We analysed the usefulness of these cytokines as biomarkers of type 2 diabetes in a Spanish cohort, together with their relationship to food consumption in the setting of the Di@bet.es study.RESEARCH DESIGN AND METHODSThis is a cross-sectional, matched case-control study of 514 type 2 diabetes subjects and 517 controls with a Normal Oral Glucose Tolerance Test (NOGTT), using data from the Di@bet.es study. Study variables included clinical and demographic structured survey, food frequency questionnaire and physical examination. Serum concentrations of sTWEAK and sCD163 were measured by ELISA. Linear regression analysis determined which variables were related to sTWEAK and sCD163 levels. Logistic regression analysis was used to estimate odd ratios of presenting type 2 diabetes.RESULTSsCD163 concentrations and sCD163/sTWEAK ratio were 11.0% and 15.0% higher, respectively, (P<0.001) in type 2 diabetes than in controls. Following adjustment for various confounders, the OR for presenting type 2 diabetes in subjects in the highest vs the lowest tertile of sCD163 was [(OR), 2,01 (95%CI, 1,46-2,97); P for trend <0.001]. Coffee and red wine consumption was negatively associated with serum levels of sCD163 (P = 0.0001 and; P = 0.002 for coffee and red wine intake, respectively).CONCLUSIONSHigh circulating levels of sCD163 are associated with type 2 diabetes in the Spanish population. The association between coffee and red wine intake and these biomarkers deserves further study to confirm its potential role in type 2 diabetes.
PB Public Library of Science
YR 2014
FD 2014-06-30
LK http://hdl.handle.net/10668/1990
UL http://hdl.handle.net/10668/1990
LA en
NO Rojo-Martínez G, Maymó-Masip E, Rodríguez MM, Solano E, Goday A, Soriguer F, et al. Serum sCD163 levels are associated with type 2 diabetes mellitus and are influenced by coffee and wine consumption: results of the Di@bet.es study. PLoS ONE. 2014; 9(6):e101250
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 12, 2025