RT Journal Article
T1 Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study.
A1 Meidtner, Karina
A1 Podmore, Clara
A1 Kröger, Janine
A1 van der Schouw, Yvonne T
A1 Bendinelli, Benedetta
A1 Agnoli, Claudia
A1 Arriola, Larraitz
A1 Barricarte, Aurelio
A1 Boeing, Heiner
A1 Cross, Amanda J
A1 Dow, Courtney
A1 Ekblom, Kim
A1 Fagherazzi, Guy
A1 Franks, Paul W
A1 Gunter, Marc J
A1 Huerta, José María
A1 Jakszyn, Paula
A1 Jenab, Mazda
A1 Katzke, Verena A
A1 Key, Timothy J
A1 Khaw, Kay Tee
A1 Kühn, Tilman
A1 Kyrø, Cecilie
A1 Mancini, Francesca Romana
A1 Melander, Olle
A1 Nilsson, Peter M
A1 Overvad, Kim
A1 Palli, Domenico
A1 Panico, Salvatore
A1 Quirós, J Ramón
A1 Rodríguez-Barranco, Miguel
A1 Sacerdote, Carlotta
A1 Sluijs, Ivonne
A1 Stepien, Magdalena
A1 Tjonneland, Anne
A1 Tumino, Rosario
A1 Forouhi, Nita G
A1 Sharp, Stephen J
A1 Langenberg, Claudia
A1 Schulze, Matthias B
A1 Riboli, Elio
A1 Wareham, Nicholas J
AB Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes. The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression. Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (β = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (-0.019 [-0.043; 0.006]) or transferrin saturation (0.016 [-0.006; 0.037]). Five SNPs located in four genes (rs1799945 [HFE H63D], rs1800562 [HFE C282Y], rs236918 [PCK7], rs744653 [SLC40A1], and rs855791 [TMPRSS6 V736A]) were associated with ferritin. We did not detect an interaction of heme iron and the gene score on the risk of diabetes in the overall study population (Padd = 0.16, Pmult = 0.21) but did detect a trend toward a negative interaction in men (Padd = 0.04, Pmult = 0.03). We found no convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with type 2 diabetes risk above the level expected from the sum or product of the two individual exposures.
YR 2017
FD 2017-11-22
LK http://hdl.handle.net/10668/11836
UL http://hdl.handle.net/10668/11836
LA en
DS RISalud
RD Apr 19, 2025