RT Journal Article
T1 Characteristics and Predictors of Progression Interstitial Lung Disease in Rheumatoid Arthritis Compared with Other Autoimmune Disease: A Retrospective Cohort Study.
A1 Mena-Vázquez, Natalia
A1 Rojas-Gimenez, Marta
A1 Romero-Barco, Carmen María
A1 Manrique-Arija, Sara
A1 Hidalgo Conde, Ana
A1 Arnedo Díez de Los Ríos, Rocío
A1 Cabrera César, Eva
A1 Ortega-Castro, Rafaela
A1 Espildora, Francisco
A1 Aguilar-Hurtado, María Carmen
A1 Añón-Oñate, Isabel
A1 Pérez-Albaladejo, Lorena
A1 Abarca-Costalago, Manuel
A1 Ureña-Garnica, Inmaculada
A1 Velloso-Feijoo, Maria Luisa
A1 Redondo-Rodriguez, Rocio
A1 Fernández-Nebro, Antonio
K1 interstitial lung disease
K1 prognosis
K1 rheumatoid arthritis
K1 systemic autoimmune disease
AB To describe the characteristics and progression of interstitial lung disease in patients with associated systemic autoimmune disease (ILD-SAI) and to identify factors associated with progression and mortality. We performed a multicenter, retrospective, observational study of patients with ILD-SAI followed between 2015 and 2020. We collected clinical data and performed pulmonary function testing and high-resolution computed tomography at diagnosis and at the final visit. The main outcome measure at the end of follow-up was forced vital capacity (FVC) >10% or diffusing capacity of the lungs for carbon monoxide >15% and radiological progression or death. Cox regression analysis was performed to identify factors associated with worsening of ILD. We included 204 patients with ILD-SAI: 123 (60.3%) had rheumatoid arthritis (RA), 58 had (28.4%) systemic sclerosis, and 23 (11.3%) had inflammatory myopathy. After a median (IQR) period of 56 (29.8-93.3) months, lung disease had stabilized in 98 patients (48%), improved in 33 (16.1%), and worsened in 44 (21.5%). A total of 29 patients (14.2%) died. Progression and hospitalization were more frequent in patients with RA (p = 0.010). The multivariate analysis showed the independent predictors for worsening of ILD-SAI to be RA (HR, 1.9 [95% CI, 1.3-2.7]), usual interstitial pneumonia pattern (HR, 1.7 [95% CI, 1.0-2.9]), FVC (%) (HR, 2.3 [95% CI, 1.4-3.9]), and smoking (HR, 2.7 [95%CI, 1.6-4.7]). Disease stabilizes or improves after a median of 5 years in more than half of patients with ILD-SAI, although more than one-third die. Data on subgroups and risk factors could help us to predict poorer outcomes.
SN 2075-4418
YR 2021
FD 2021-09-28
LK https://hdl.handle.net/10668/25698
UL https://hdl.handle.net/10668/25698
LA en
DS RISalud
RD Apr 8, 2025