RT Journal Article
T1 Obesity and metabolic dysfunction severely influence prostate cell function: role of insulin and IGF1.
A1 L-Lopez, Fernando
A1 Sarmento-Cabral, Andre
A1 Herrero-Aguayo, Vicente
A1 Gahete, Manuel D
A1 Castaño, Justo P
A1 Luque, Raul M
K1 IGF1
K1 Insulin
K1 Obesity
K1 Prostate
K1 Prostate cancer
AB Obesity is a major health problem that courses with severe comorbidities and a drastic impairment of homeostasis and function of several organs, including the prostate gland (PG). The endocrine-metabolic regulatory axis comprising growth hormone (GH), insulin and IGF1, which is drastically altered under extreme metabolic conditions such as obesity, also plays relevant roles in the development, modulation and homeostasis of the PG. However, its implication in the pathophysiological interplay between obesity and prostate function is still to be elucidated. To explore this association, we used a high fat-diet obese mouse model, as well as in vitro primary cultures of normal-mouse PG cells and human prostate cancer cell lines. This approach revealed that most of the components of the GH/insulin/IGF1 regulatory axis are present in PGs, where their expression pattern is altered under obesity conditions and after an acute insulin treatment (e.g. Igfbp3), which might have some pathophysiological implications. Moreover, our results demonstrate, for the first time, that the PG becomes severely insulin resistant under diet-induced obesity in mice. Finally, use of in vitro approaches served to confirm and expand the conception that insulin and IGF1 play a direct, relevant role in the control of normal and pathological PG cell function. Altogether, these results uncover a fine, germane crosstalk between the endocrine-metabolic status and the development and homeostasis of the PG, wherein key components of the GH, insulin and IGF1 axes could play a relevant pathophysiological role.
PB Wiley
YR 2017
FD 2017-01-01
LK http://hdl.handle.net/10668/10913
UL http://hdl.handle.net/10668/10913
LA en
NO L-López F, Sarmento-Cabral A, Herrero-Aguayo V, Gahete MD, Castaño JP, Luque RM. Obesity and metabolic dysfunction severely influence prostate cell function: role of insulin and IGF1. J Cell Mol Med. 2017 Sep;21(9):1893-1904
NO This work was supported by the following grants: BIO-0139, CTS-1406, PI0639-2012, PI-0541-2013 (Junta de Andaluc ıa), PI13-00651, PI16/00264,PIE14/00005 [Instituto de Salud Carlos III, and co-funded by European Union(ERDF/ESF, “Investing in your future”)], BFU2013-43282-R (Ministerio deEconom ıa y Competitividad), CIBERobn and Ayuda Merck Serono 2013.
DS RISalud
RD Apr 14, 2025