RT Journal Article
T1 A Versatile Nanocarrier-Cubosomes, Characterization, and Applications.
A1 Oliveira, Cristiana
A1 Ferreira, Celso J O
A1 Sousa, Miguel
A1 Paris, Juan L
A1 Gaspar, Ricardo
A1 Silva, Bruno F B
A1 Teixeira, José A
A1 Ferreira-Santos, Pedro
A1 Botelho, Claudia M
K1 cubosomes
K1 delivery systems
K1 nanomedicine
K1 nanotechnology
AB The impact of nanotechnology on the exponential growth of several research areas, particularly nanomedicine, is undeniable. The ability to deliver active molecules to the desired site could significantly improve the efficiency of medical treatments. One of the nanocarriers developed which has drawn researchers' attention are cubosomes, which are nanosized dispersions of lipid bicontinuous cubic phases in water, consisting of a lipidic interior and aqueous domains folded in a cubic lattice. They stand out due to their ability to incorporate hydrophobic, hydrophilic, and amphiphilic compounds, their tortuous internal configuration that provides a sustained release, and the capacity to protect and safely deliver molecules. Several approaches can be taken to prepare this structure, as well as different lipids like monoolein or phytantriol. This review paper describes the different methods to prepare nanocarriers. As it is known, the physicochemical properties of nanocarriers are very important, as they influence their pharmacokinetics and their ability to incorporate and deliver active molecules. Therefore, an extensive characterization is essential to obtain the desired effect. As a result, we have extensively described the most common techniques to characterize cubosomes, particularly nanocarriers. The exceptional properties of the cubosomes make them suitable to be used in several applications in the biomedical field, from cancer therapeutics to imaging, which will be described. Taking in consideration the outstanding properties of cubosomes, their application in several research fields is envisaged.
SN 2079-4991
YR 2022
FD 2022-06-29
LK http://hdl.handle.net/10668/21444
UL http://hdl.handle.net/10668/21444
LA en
DS RISalud
RD Apr 10, 2025