RT Journal Article
T1 Growth hormone-releasing hormone-secreting pulmonary neuroendocrine tumor associated with pituitary hyperplasia and somatotropinoma
A1 Lamback, Elisa B.
A1 Henriques, Daniel G.
A1 Vazquez-Borrego, Mari C.
A1 de Azeredo Lima, Carlos H.
A1 Kasuki, Leandro
A1 Luque, Raul M.
A1 Chimelli, Leila
A1 Gadelha, Monica R.
K1 Men1 gene-mutations
K1 Ectopic secretion
K1 Endocrine tumors
K1 Carcinoid-tumor
K1 Ghrh
K1 Tumorigenesis
AB Acromegaly caused by ectopic growth hormone-releasing hormone (GHRH)-secreting tumor is exceedingly rare. We report a case of acromegaly secondary to GHRH secretion by an incidentally diagnosed pulmonary neuroendocrine tumor (NET) and review 47 similar cases in literature. A 22-year-old male patient presented with symptoms of pituitary apoplexy. Magnetic resonance imaging (MRI) showed apoplexy of a pituitary adenoma. Routinely prior to surgery, a chest radiography was performed which revealed a mass in the left lung. During investigation, the patient was diagnosed with metastatic GHRH-secreting pulmonary NET. In retrospect, it was noted that the patient had pituitary hyperplasia 20 months prior to the MRI which showed the presence of a pituitary adenoma. The histological findings confirmed somatotroph hyperplasia adjacent to somatotropinoma. This case suggests that GHRH secretion can be associated with pituitary hyperplasia, which may be followed by pituitary adenoma formation.
PB Sbem-soc brasil endocrinologia & metabologia
SN 2359-3997
YR 2021
FD 2021-09-01
LK https://hdl.handle.net/10668/25614
UL https://hdl.handle.net/10668/25614
LA en
DS RISalud
RD Apr 11, 2025