RT Journal Article
T1 Sustained Improvement of Left Ventricular Strain following Transcatheter Aortic Valve Replacement.
A1 Lozano Granero, Vanesa Cristina
A1 Fernández Santos, Sara
A1 Fernández-Golfín, Covadonga
A1 González Gómez, Ariana
A1 Plaza Martín, María
A1 de la Hera Galarza, Jesús María
A1 Faletra, Francesco Fulvio
A1 Swaans, Martin J
A1 López-Fernández, Teresa
A1 Mesa, Dolores
A1 La Canna, Giovanni
A1 Echeverría García, Tomás
A1 Habib, Gilbert
A1 Martínez Monzonís, Amparo
A1 Zamorano Gómez, José Luis
A1 SITAR (Strain Imaging in Transcatheter Aortic-Valve Replacement) group, 
K1 Aortic stenosis
K1 Echocardiography
K1 Left ventricular mechanics
K1 Strain
K1 Transcatheter aortic valve replacement
AB Left ventricular (LV) mechanics are impaired in patients with severe aortic stenosis (AS). Transcatheter aortic valve replacement (TAVR) has become a widespread technique for patients with severe AS considered inoperable or high risk for open surgery. This procedure could have a positive impact in LV mechanics. The aim of the study was to evaluate the effect of TAVR on LV function recovery, as assessed by myocardial deformation parameters, both immediately and in the long term. One-hundred nineteen consecutive patients (81.2 ± 6.9 years, 50.4% female) from 10 centres in Europe with severe AS who successfully underwent TAVR with either a self-expanding CoreValve (Medtronic, Minneapolis, MN, USA) or a mechanically expanded Lotus valve (Boston Scientific, Natick, MA, USA) were enrolled in a prospective observational study. A complete echocardiographic examination was performed prior to device implantation, before discharge and 1 year after the procedure, including the assessment of LV strain using standard 2D images. Between baseline and discharge, only a modest but statistically significant improvement in GLS (global longitudinal strain) could be seen (GLS% -14.6 ± 5.0 at baseline; -15.7 ± 5.1 at discharge, p = 0.0116), although restricted to patients in the CoreValve group; 1 year after the procedure, a greater improvement in GLS was observed (GLS% -17.1 ± 4.9, p  Immediate and sustained improvement in GLS was appreciated after the TAVR procedure. Whether this finding continues to be noted in a more prolonged follow-up and its clinical implications need to be assessed in further studies.
YR 2019
FD 2019-07-15
LK http://hdl.handle.net/10668/14243
UL http://hdl.handle.net/10668/14243
LA en
DS RISalud
RD Apr 6, 2025