%0 Journal Article
%A Sanchez-Diener, I
%A Zamorano, L
%A Peña, C
%A Ocampo-Sosa, A
%A Cabot, G
%A Gomez-Zorrilla, S
%A Almirante, B
%A Aguilar, M
%A Granados, A
%A Calbo, E
%A Rodriguez-Baño, J
%A Rodriguez-Lopez, F
%A Tubau, F
%A Martinez-Martinez, L
%A Navas, A
%A Oliver, A
%T Weighting the impact of virulence on the outcome of Pseudomonas aeruginosa bloodstream infections.
%D 2019
%U http://hdl.handle.net/10668/14230
%X We assessed the association between the lethality of Pseudomonas aeruginosa in a Caenorhabditis elegans model and outcomes of P. aeruginosa bloodstream infections. A total of 593 P. aeruginosa bloodstream isolates recovered from a prospective Spanish multicentre study were analysed. Clinical variables, susceptibility profiles and Type III Secretion System (TTSS) genotypes (exoU/exoS genes) were available from previous studies. A C. elegans virulence score (CEVS) was used, classifying the isolates into high (CEVS 4-5), intermediate (CEVS 3) and low (CEVS 1-2) virulence. The main outcome analysed was 30-day mortality. Up to 75% (446/593) of the isolates showed a high-virulence phenotype, and 17% (101/593) a low-virulence one. No association between virulence phenotype and the main outcome variable (30-day mortality) was found (29/101 (28.7%) versus 127/446 (28.5%), p 1). However, an inverse association between C. elegans virulence and multidrug-resistant and extensively drug-resistant profiles was documented (OR 0.655 (95% CI 0.571-0.751) and OR 0.523 (95% CI 0.436-0.627), p  Our results indicate that the P. aeruginosa virulence phenotype in a C. elegans model correlates with virulence genotype (TTSS) and resistance profile, but it is a poor prognostic marker of mortality in bloodstream infections.
%K Bloodstream infections
%K Caenorhabditis elegans
%K Pseudomonas aeruginosa
%K Virulence
%~