RT Journal Article
T1 Pathophysiology of Circulating Biomarkers and Relationship With Vascular Aging: A Review of the Literature From VascAgeNet Group on Circulating Biomarkers, European Cooperation in Science and Technology Action 18216.
A1 Gopcevic, Kristina R
A1 Gkaliagkousi, Eugenia
A1 Nemcsik, János
A1 Acet, Ömür
A1 Bernal-Lopez, M Rosa
A1 Bruno, Rosa M
A1 Climie, Rachel E
A1 Fountoulakis, Nikolaos
A1 Fraenkel, Emil
A1 Lazaridis, Antonios
A1 Navickas, Petras
A1 Rochfort, Keith D
A1 Šatrauskienė, Agnė
A1 Zupkauskienė, Jūratė
A1 Terentes-Printzios, Dimitrios
K1 cellular matrix
K1 circulating biomarkers
K1 epigenetics
K1 inflammation
K1 oxidative stress
K1 vascular aging
AB Impairment of the arteries is a product of sustained exposure to various deleterious factors and progresses with time; a phenomenon inherent to vascular aging. Oxidative stress, inflammation, the accumulation of harmful agents in high cardiovascular risk conditions, changes to the extracellular matrix, and/or alterations of the epigenetic modification of molecules, are all vital pathophysiological processes proven to contribute to vascular aging, and also lead to changes in levels of associated circulating molecules. Many of these molecules are consequently recognized as markers of vascular impairment and accelerated vascular aging in clinical and research settings, however, for these molecules to be classified as biomarkers of vascular aging, further criteria must be met. In this paper, we conducted a scoping literature review identifying thirty of the most important, and eight less important, biomarkers of vascular aging. Herein, we overview a selection of the most important molecules connected with the above-mentioned pathological conditions and study their usefulness as circulating biomarkers of vascular aging.
SN 1664-042X
YR 2021
FD 2021-12-14
LK https://hdl.handle.net/10668/24489
UL https://hdl.handle.net/10668/24489
LA en
DS RISalud
RD Apr 11, 2025