TY - JOUR AU - Thomas, M AU - Ponce-Aix, S AU - Navarro, A AU - Riera-Knorrenschild, J AU - Schmidt, M AU - Wiegert, E AU - Kapp, K AU - Wittig, B AU - Mauri, C AU - Dómine Gómez, M AU - Kollmeier, J AU - Sadjadian, P AU - Fröhling, K-P AU - Huber, R M AU - Wolf, M AU - IMPULSE study team PY - 2018 DO - 10.1093/annonc/mdy326 UR - https://hdl.handle.net/10668/26886 T2 - Annals of oncology : official journal of the European Society for Medical Oncology AB - The immune surveillance reactivator lefitolimod (MGN1703), a DNA-based TLR9 agonist, might foster innate and adaptive immune response and thus improve immune-mediated control of residual cancer disease. The IMPULSE phase II study evaluated the... LA - en KW - Antineoplastic Combined Chemotherapy Protocols KW - Carboplatin KW - Cisplatin KW - Cohort Studies KW - Etoposide KW - Follow-Up Studies KW - Humans KW - Immunosuppressive Agents KW - Immunotherapy KW - International Agencies KW - Leflunomide KW - Lung Neoplasms KW - Maintenance Chemotherapy KW - Prognosis KW - Small Cell Lung Carcinoma KW - Survival Rate KW - Toll-Like Receptor 9 TI - Immunotherapeutic maintenance treatment with toll-like receptor 9 agonist lefitolimod in patients with extensive-stage small-cell lung cancer: results from the exploratory, controlled, randomized, international phase II IMPULSE study. TY - research article VL - 29 ER -