RT Journal Article
T1 Busulfan-based reduced intensity conditioning regimens for haploidentical transplantation in relapsed/refractory Hodgkin lymphoma: Spanish multicenter experience.
A1 Gayoso, J
A1 Balsalobre, P
A1 Pascual, M J
A1 Castilla-Llorente, C
A1 Lopez-Corral, L
A1 Kwon, M
A1 Serrano, D
A1 Piñana, J L
A1 Herrera, P
A1 Ferra, C
A1 Pascual, C
A1 Heras, I
A1 Montesinos, P
A1 Zabalza, A
A1 Bento, L
A1 Figuera, A
A1 Buño, I
A1 Diez-Martin, J L
K1 Spain
K1 Survival Analysis
K1 Transplantation Conditioning
K1 Transplantation, Haploidentical
K1 Young Adult
AB Relapsed or refractory Hodgkin lymphoma (advanced HL) still remains a therapeutic challenge. Recently, unmanipulated haploidentical related donor transplant with reduced conditioning regimen (HAPLO-RIC) and post-transplant cyclophosphamide (PT-Cy) as GvHD prophylaxis has became a promising rescue strategy potentially available to almost every patient. This paper reports our multicenter experience using an IV busulfan-based HAPLO-RIC regimen and PT-Cy in the treatment of 43 patients with advanced HL. Engraftment occurred in 42 patients (97.5%), with a median time to neutrophil and platelet recovery of 18 and 26 days. Cumulative incidences of grades II-IV acute GvHD and chronic GvHD were 39% and 19%, respectively. With a median follow-up of 25.5 months for survivors, 27 patients are alive, with 22 of them disease free. Cumulative incidences of 1-year non-relapse mortality and relapse at 2 years were 21% and 24%, respectively. The estimated 2-year event-free survival (EFS) and overall survival (OS) were 48% and 58%, respectively. CR prior to HAPLO-RIC correlated with better EFS (78.5% vs 33.5%; P=0.015) and OS (86% vs 46%; P=0.044). Our findings further confirm prior reports using HAPLO-RIC in advanced HL in a multicenter approach employing an IV busulfan-based conditioning regimen.
PB Nature Publishing Group
YR 2016
FD 2016-05-09
LK http://hdl.handle.net/10668/10067
UL http://hdl.handle.net/10668/10067
LA en
NO Gayoso J, Balsalobre P, Pascual MJ, Castilla-Llorente C, López-Corral L, Kwon M, et al. Busulfan-based reduced intensity conditioning regimens for haploidentical transplantation in relapsed/refractory Hodgkin lymphoma: Spanish multicenter experience. Bone Marrow Transplant. 2016 Oct;51(10):1307-1312
NO This work was partially supported by the Ministry of Economy and Competitiveness ISCIII-FIS grants PI11/00708, PI14/01731 and RD12/0036/0061, co-financed by ERDF (FEDER) Funds from the European Commission, ‘A way of making Europe’, as well as grants from Asociación Española Contra el Cáncer (AECC) and Fundación Mutua Madrileña (FMM).
DS RISalud
RD Apr 26, 2025