RT Journal Article
T1 Heterogeneity of DNA damage incidence and repair in different chromatin contexts.
A1 Ortega, Pedro
A1 Gómez-González, Belén
A1 Aguilera, Andrés
K1 Chromatin
K1 DNA damage
K1 DNA repair
K1 Double-strand break
K1 Genome instability
AB It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent advances have determined a critical role of chromatin both in the incidence of damage and in its repair. Thus, chromatin arises as a guardian of the stability of the genome, which is altered in cancer cells. In this review, we focus into the mechanisms by which chromatin influences the occurrence and repair of the most cytotoxic DNA lesions, double-strand breaks, in particular at actively transcribed chromatin or related to DNA replication.
YR 2021
FD 2021-08-13
LK https://hdl.handle.net/10668/28354
UL https://hdl.handle.net/10668/28354
LA en
DS RISalud
RD Apr 6, 2025