RT Journal Article
T1 The Metabolic Impact of Two Different Parenteral Nutrition Lipid Emulsions in Children after Hematopoietic Stem Cell Transplantation: A Lipidomics Investigation.
A1 Rangel-Huerta, Oscar Daniel
A1 de la Torre-Aguilar, Maria Jose
A1 Mesa, Maria Dolores
A1 Flores-Rojas, Katherine
A1 Perez-Navero, Juan Luis
A1 Baena-Gomez, Maria Auxiliadora
A1 Gil, Angel
A1 Gil-Campos, Mercedes
K1 Bone marrow transplantation
K1 Fat emulsions
K1 Fatty acids
K1 Hematopoietic stem cell transplantation
K1 Intravenous
K1 Lipidomics
K1 Omega-3
K1 Parenteral nutrition
AB Hematopoietic stem cell transplantation (HSCT) involves the infusion of either bone marrow or blood cells preceded by toxic chemotherapy. However, there is little knowledge about the clinical benefits of parenteral nutrition (PN) in patients receiving high-dose chemotherapy during HSCT. We investigated the lipidomic profile of plasma and the targeted fatty acid profiles of plasma and erythrocytes in children after HSCT using PN with either a fish oil-based lipid emulsion or a classic soybean oil emulsion. An untargeted liquid chromatography high-resolution mass spectrometry platform connected with a novel in silico annotation algorithm was utilized to determine the most relevant chemical subclasses affected. In addition, we explored the interrelation between the lipidomics profile in plasma, the targeted fatty acid profile in plasma and erythrocytes, several biomarkers of inflammation, and antioxidant defense using an innovative data integration analysis based on Latent Components. We observed that the fish oil-based lipid emulsion had an impact in several lipid subclasses, mainly glycerophosphocholines (PC), glycerophosphoserines (PS), glycerophosphoethanolamines (PE), oxidized PE (O-PE), 1-alkyl,2-acyl PS, lysophosphatidylethanolamines (LPE), oxidized PS (O-PS) and dicarboxylic acids. In contrast, the classic soybean oil emulsion did not. Several connections across the different blocks of data were found and aid in interpreting the impact of the lipid emulsions on metabolic health.
PB MDPI
YR 2022
FD 2022-02-22
LK http://hdl.handle.net/10668/21146
UL http://hdl.handle.net/10668/21146
LA en
NO Rangel-Huerta OD, de la Torre-Aguilar MJ, Mesa MD, Flores-Rojas K, Pérez-Navero JL, Baena-Gómez MA, et al. The Metabolic Impact of Two Different Parenteral Nutrition Lipid Emulsions in Children after Hematopoietic Stem Cell Transplantation: A Lipidomics Investigation. Int J Mol Sci. 2022 Mar 27;23(7):3667
DS RISalud
RD Apr 12, 2025