%0 Journal Article
%A Rivera-Izquierdo, Mario
%A Soler-Iborte, Eva
%A de Rojas, Javier Perez
%A Pegalajar-Garcia, Maria Dolores
%A Gil-Villalba, Ana
%A Ruiz-Villaverde, Ricardo
%A Valero-Ubierna, Maria Del Carmen
%T Factors Associated with Adverse Reactions to BNT162b2 COVID-19 Vaccine in a Cohort of 3969 Hospital Workers.
%D 2021
%@ 2076-393X
%U http://hdl.handle.net/10668/21604
%X Factors associated with adverse reactions to BNT162b2 COVID-19 vaccine reported by hospital workers are unclear. Our aim was to collect all reported adverse events in a cohort of hospital workers and to analyze the factors associated with their presence. We conducted an observational longitudinal study on all hospital workers of our center who received COVID-19 vaccination from 27 December 2020 to 1 September 2021. Information on adverse events was reported telephonically and confirmed through clinical records. Chi-square and t tests as well as multivariate logistic regression models were used. Cluster analysis was designed to explore associations between reactions. A total of 3969 hospital workers were included in the sample. Of the total sample, 182 workers (4.6%) reported adverse events. The most frequent symptoms were general malaise (n = 95), fever (n = 92), arthromyalgia (n = 80), and headache (n = 47). The factors associated with adverse events in adjusted analyses were an antecedent of COVID-19 infection (OR = 2.09, 95% CI: 1.47-2.98), female sex (OR = 1.51, 95% CI: 1.03-2.20), and professional category (OR for physicians = 0.41, 95% CI: 0.21-0.80). We report a low frequency of adverse events in hospital workers after COVID-19 vaccination and no severe reaction. Men and physicians underreported their symptoms. These data should guide future strategies for recording adverse events and future research on COVID-19 vaccination safety.
%K COVID-19
%K Comirnaty
%K Pfizer
%K adverse events
%K healthcare
%K professionals
%K reactions
%K symptoms
%K vaccination
%~