RT Journal Article
T1 Moringa oleifera Leaf Supplementation as a Glycemic Control Strategy in Subjects with Prediabetes.
A1 Gómez-Martínez, Sonia
A1 Díaz-Prieto, Ligia E
A1 Vicente Castro, Iván
A1 Jurado, César
A1 Iturmendi, Nerea
A1 Martín-Ridaura, Maria Carmen
A1 Calle, Nuria
A1 Dueñas, María
A1 Picón, María J
A1 Marcos, Ascensión
A1 Nova, Esther
K1 Moringa oleifera
K1 food supplement
K1 gastrointestinal hormones
K1 glycemic control
K1 gut microbiota
K1 polyphenol-rich plant food
K1 prediabetes
AB Moringa oleifera (MO) is a multipurpose plant with a high polyphenol content, which is being increasingly consumed to lessen the risk of chronic metabolic diseases such as Type 2 diabetes; however, scientific evidence from clinical trials is scarce. A double-blind, randomized, placebo-controlled, parallel group intervention study with MO leaves as a food supplement was conducted in subjects with prediabetes. They consumed six daily capsules of MO dry leaf powder (2400 mg/day) (MO, n = 31) or placebo (PLC, n = 34) over 12 weeks. Glycemia, appetite-controlling hormones and gut microbiota composition were studied. ANCOVA with the fixed factor "treatment" and the basal value as covariate was used to compare the change score between the groups. The results showed significant differences between groups in the rate of change of fasting blood glucose (FBG) and glycated hemoglobin (HbA1c), which showed opposite directions during the intervention, decreasing in MO and increasing in PLC. No different change scores were found between the groups in microbiota, hepatic and renal function markers or the appetite-controlling hormones measured. In conclusion, MO supplementation resulted in favorable changes in glycaemia markers compared to placebo in the subjects with prediabetes studied, suggesting that MO might act as a natural antihyperglycemic agent.
YR 2021
FD 2021-12-24
LK http://hdl.handle.net/10668/21448
UL http://hdl.handle.net/10668/21448
LA en
DS RISalud
RD Apr 8, 2025