RT Journal Article
T1 Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study.
A1 Papantoniou, Kyriaki
A1 Castaño-Vinyals, Gemma
A1 Espinosa, Ana
A1 Turner, Michelle C
A1 Martin-Sanchez, Vicente
A1 Casabonne, Delphine
A1 Aragones, Nuria
A1 Gomez-Acebo, Ines
A1 Ardanaz, Eva
A1 Jimenez-Moleon, Jose-Juan
A1 Amiano, Pilar
A1 Molina-Barcelo, Ana
A1 Alguacil, Juan
A1 Fernandez-Tardon, Guillermo
A1 Huerta, Jose Maria
A1 Hernandez-Segura, Natalia
A1 Perez-Gomez, Beatriz
A1 Llorca, Javier
A1 Vidan-Alli, Juana
A1 Olmedo-Requena, Rocıo
A1 Gil, Leire
A1 Castañon-Lopez, Carmen
A1 Pollan, Marina
A1 Kogevinas, Manolis
A1 Moreno, Victor
K1 Risk factors
K1 Gastroenterology
K1 Cancer
AB Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case-control study (2008-2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multivariable adjusted logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (CI) for cancer, across categories of sleep duration (≤ 5, 6, 7, 8, ≥ 9 hours/day), daytime napping frequency (naps/week) and duration (minutes/nap). Compared to 7 hours of sleep, long sleep was associated with increased odds of colorectal (OR≥9 hours: 1.59; 95%CI 1.30-1.94) and gastric cancer (OR≥9 hours: 1.95; 1.37-2.76); short sleep was associated with increased odds of gastric cancer (OR≤5 hours: 1.32; 0.93-1.88). Frequent and long daytime naps increased the odds of colorectal (OR6-7 naps/week, ≥30 min: 1.32; 1.14-1.54) and gastric cancer (OR6-7 naps/week, ≥30 min: 1.56; 1.21-2.02). Effects of short sleep and frequent long naps were stronger among participants with night shift-work history. Sleep and circadian disruption may jointly play a role in the etiology of colorectal and gastric cancer.
PB Nature Publishing Group
YR 2021
FD 2021-05-20
LK http://hdl.handle.net/10668/17950
UL http://hdl.handle.net/10668/17950
LA en
NO Papantoniou K, Castaño-Vinyals G, Espinosa A, Turner MC, Martín-Sánchez V, Casabonne D, et al. Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study. Sci Rep. 2021 Jun 3;11(1):11822.
DS RISalud
RD Apr 17, 2025