%0 Journal Article
%A Papantoniou, Kyriaki
%A Castaño-Vinyals, Gemma
%A Espinosa, Ana
%A Turner, Michelle C
%A Martin-Sanchez, Vicente
%A Casabonne, Delphine
%A Aragones, Nuria
%A Gomez-Acebo, Ines
%A Ardanaz, Eva
%A Jimenez-Moleon, Jose-Juan
%A Amiano, Pilar
%A Molina-Barcelo, Ana
%A Alguacil, Juan
%A Fernandez-Tardon, Guillermo
%A Huerta, Jose Maria
%A Hernandez-Segura, Natalia
%A Perez-Gomez, Beatriz
%A Llorca, Javier
%A Vidan-Alli, Juana
%A Olmedo-Requena, Rocıo
%A Gil, Leire
%A Castañon-Lopez, Carmen
%A Pollan, Marina
%A Kogevinas, Manolis
%A Moreno, Victor
%T Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study.
%D 2021
%U http://hdl.handle.net/10668/17950
%X Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case-control study (2008-2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multivariable adjusted logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (CI) for cancer, across categories of sleep duration (≤ 5, 6, 7, 8, ≥ 9 hours/day), daytime napping frequency (naps/week) and duration (minutes/nap). Compared to 7 hours of sleep, long sleep was associated with increased odds of colorectal (OR≥9 hours: 1.59; 95%CI 1.30-1.94) and gastric cancer (OR≥9 hours: 1.95; 1.37-2.76); short sleep was associated with increased odds of gastric cancer (OR≤5 hours: 1.32; 0.93-1.88). Frequent and long daytime naps increased the odds of colorectal (OR6-7 naps/week, ≥30 min: 1.32; 1.14-1.54) and gastric cancer (OR6-7 naps/week, ≥30 min: 1.56; 1.21-2.02). Effects of short sleep and frequent long naps were stronger among participants with night shift-work history. Sleep and circadian disruption may jointly play a role in the etiology of colorectal and gastric cancer.
%K Risk factors
%K Gastroenterology
%K Cancer
%~