RT Journal Article
T1 Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000-2015.
A1 Perez-Nadales, Elena
A1 Alastruey-Izquierdo, Ana
A1 Linares-Sicilia, Maria Jose
A1 Soto-Debran, Juan Carlos
A1 Abdala, Edson
A1 García-Rodriguez, Julio
A1 Montejo, Miguel
A1 Muñoz, Patricia
A1 Lleti, Miguel Salavert
A1 Rezusta, Antonio
A1 de Pipaon, Maite Ruiz Perez
A1 Yañez, Lucrecia
A1 Merino, Esperanza
A1 Campos-Herrero, Maria Isolina
A1 Costa-Mateo, Jose Maria
A1 Fortun, Jesus
A1 Garcia-Lozano, Tomas
A1 Garcia-Vidal, Carolina
A1 Fernandez-Ruiz, Mario
A1 Sanchez-Reus, Ferran
A1 Castro-Mendez, Carmen
A1 Guerrero-Lozano, Inmaculada
A1 Soler-Palacin, Pere
A1 Aguado, Jose Maria
A1 Martinez-Martinez, Luis
A1 Torre-Cisneros, Julian
A1 Nucci, Marcio
K1 Fusarium
K1 Spain
K1 Fungal infections
K1 Fungi
K1 Fusariosis
K1 Incidence
K1 Invasive fusariosis
K1 Mortality
K1 Mycotic diseases
K1 Neutropenia
K1 Área de Gestión Sanitaria Sur de Sevilla
AB Invasive fusariosis (IF) is associated with severe neutropenia in patients with concurrent hematologic conditions. We conducted a retrospective observational study to characterize the epidemiology of IF in 18 Spanish hospitals during 2000-2015. In that time, the frequency of IF in nonneutropenic patients increased from 0.08 cases per 100,000 admissions in 2000-2009 to 0.22 cases per 100,000 admissions in 2010-2015. Nonneutropenic IF patients often had nonhematologic conditions, such as chronic cardiac or lung disease, rheumatoid arthritis, history of solid organ transplantation, or localized fusariosis. The 90-day death rate among nonneutropenic patients (28.6%) and patients with resolved neutropenia (38.1%) was similar. However, the death rate among patients with persistent neutropenia (91.3%) was significantly higher. We used a multivariate Cox regression analysis to characterize risk factors for death: persistent neutropenia was the only risk factor for death, regardless of antifungal therapy.
PB U.S. Department of Health and Human Services * Centers for Disease Control and Prevention
YR 2021
FD 2021
LK http://hdl.handle.net/10668/16833
UL http://hdl.handle.net/10668/16833
LA en
NO Pérez-Nadales E, Alastruey-Izquierdo A, Linares-Sicilia MJ, Soto-Debrán JC, Abdala E, García-Rodríguez J, et al. Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000-2015. Emerg Infect Dis. 2021 Jan;27(1):26–3
DS RISalud
RD Apr 5, 2025