%0 Journal Article
%A Perez-Nadales, Elena
%A Alastruey-Izquierdo, Ana
%A Linares-Sicilia, Maria Jose
%A Soto-Debran, Juan Carlos
%A Abdala, Edson
%A García-Rodriguez, Julio
%A Montejo, Miguel
%A Muñoz, Patricia
%A Lleti, Miguel Salavert
%A Rezusta, Antonio
%A de Pipaon, Maite Ruiz Perez
%A Yañez, Lucrecia
%A Merino, Esperanza
%A Campos-Herrero, Maria Isolina
%A Costa-Mateo, Jose Maria
%A Fortun, Jesus
%A Garcia-Lozano, Tomas
%A Garcia-Vidal, Carolina
%A Fernandez-Ruiz, Mario
%A Sanchez-Reus, Ferran
%A Castro-Mendez, Carmen
%A Guerrero-Lozano, Inmaculada
%A Soler-Palacin, Pere
%A Aguado, Jose Maria
%A Martinez-Martinez, Luis
%A Torre-Cisneros, Julian
%A Nucci, Marcio
%T Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000-2015.
%D 2021
%U http://hdl.handle.net/10668/16833
%X Invasive fusariosis (IF) is associated with severe neutropenia in patients with concurrent hematologic conditions. We conducted a retrospective observational study to characterize the epidemiology of IF in 18 Spanish hospitals during 2000-2015. In that time, the frequency of IF in nonneutropenic patients increased from 0.08 cases per 100,000 admissions in 2000-2009 to 0.22 cases per 100,000 admissions in 2010-2015. Nonneutropenic IF patients often had nonhematologic conditions, such as chronic cardiac or lung disease, rheumatoid arthritis, history of solid organ transplantation, or localized fusariosis. The 90-day death rate among nonneutropenic patients (28.6%) and patients with resolved neutropenia (38.1%) was similar. However, the death rate among patients with persistent neutropenia (91.3%) was significantly higher. We used a multivariate Cox regression analysis to characterize risk factors for death: persistent neutropenia was the only risk factor for death, regardless of antifungal therapy.
%K Fusarium
%K Spain
%K Fungal infections
%K Fungi
%K Fusariosis
%K Incidence
%K Invasive fusariosis
%K Mortality
%K Mycotic diseases
%K Neutropenia
%K Área de Gestión Sanitaria Sur de Sevilla
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