RT Journal Article
T1 CT-Determined Sarcopenia in GLIM-Defined Malnutrition and Prediction of 6-Month Mortality in Cancer Inpatients
A1 Sánchez-Torralvo, Francisco José
A1 Ruiz-García, Ignacio
A1 Contreras-Bolívar, Victoria
A1 González-Almendros, Inmaculada
A1 Ruiz-Vico, María
A1 Abuín-Fernández, Jose
A1 Barrios, Manuel
A1 Alba, Emilio
A1 Olveira, Gabriel
K1 Computed tomography
K1 GLIM criteria
K1 Malnutrition
K1 Oncology
K1 Body composition
AB Our objective was to evaluate the clinical application of third lumbar vertebra (L3)-computer tomography (CT)-determined sarcopenia as a marker of muscle mass in cancer inpatients diagnosed with malnutrition according to the Global Leadership Initiative on Malnutrition (GLIM) criteria and to establish its association with 6-month mortality. Methods: This was an observational, Prospective study in patients from an inpatient oncology unit. We performed a nutritional assessment according to GLIM criteria, including muscle cross-sectional area at L3 by CT and skeletal muscle index (SMI). Six-month mortality was evaluated. Results: A total of 208 patients were included. The skeletal muscle cross-sectional area at L3 was 136.2 ± 32.5 cm2 in men and 98.1 ± 21.2 cm2 in women. The SMI was 47.4 ± 12.3 cm2/m2 in men and 38.7 ± 8.3 cm2/m2 in women. Sarcopenia (low SMI) was detected in 59.6% of the subjects. Using SMI as a marker of low muscle mass in application of GLIM criteria, we found 183 (87.9%) malnourished patients. There were 104 deaths (50%) at 6 months. The deceased patients had a lower skeletal muscle cross-sectional area (112.9 ± 27.9 vs. 126.1 ± 37.8 cm2 ; p = 0.003) and a lower SMI (41.3 ± 9.5 vs. 45.7 ± 12.9 cm2/m2 ; p = 0.006). An increased risk of 6-month mortality was found in malnourished patients according to GLIM criteria using SMI (HR 2.47; 95% confidence interval 1.07–5.68; p = 0.033). Conclusions: Low muscle mass, assessed by L3-CT, was observed to affect more than half of cancer inpatients. The deceased patients at 6 months had a lower skeletal muscle cross-sectional area and SMI. Malnutrition according to GLIM criteria using CT-determined sarcopenia was shown to adequately predict 6-month mortality.
PB MDPI
YR 2021
FD 2021-07-30
LK http://hdl.handle.net/10668/4317
UL http://hdl.handle.net/10668/4317
LA en
NO Sánchez-Torralvo FJ, Ruiz-García I, Contreras-Bolívar V, González-Almendros I, Ruiz-Vico M, Abuín-Fernández J, et al. CT-Determined Sarcopenia in GLIM-Defined Malnutrition and Prediction of 6-Month Mortality in Cancer Inpatients. Nutrients. 2021 Jul 30;13(8):2647
DS RISalud
RD Sep 13, 2025