TY  - JOUR
AU  - Passerini, Laura
AU  - Barzaghi, Federica
AU  - Curto, Rosalia
AU  - Sartirana, Claudia
AU  - Barera, Graziano
AU  - Tucci, Francesca
AU  - Albarello, Luca
AU  - Mariani, Alberto
AU  - Testoni, Pier Alberto
AU  - Bazzigaluppi, Elena
AU  - Bosi, Emanuele
AU  - Lampasona, Vito
AU  - Neth, Olaf
AU  - Zama, Daniele
AU  - Hoenig, Manfred
AU  - Schulz, Ansgar
AU  - Seidel, Markus G
AU  - Rabbone, Ivana
AU  - Olek, Sven
AU  - Roncarolo, Maria G
AU  - Cicalese, Maria P
AU  - Aiuti, Alessandro
AU  - Bacchetta, Rosa
PY  - 2019
DO  - 10.1016/j.jaci.2019.11.043
UR  - http://hdl.handle.net/10668/14874
T2  - The Journal of allergy and clinical immunology
AB  - Immune-dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a lethal disease caused by mutations in a transcription factor critical for the function of thymus-derived regulatory T (Treg) cells (ie, FOXP3), resulting in impaired...
LA  - en
KW  - Ebi3
KW  - FOXP3
KW  - GITR
KW  - IPEX
KW  - autoimmunity
KW  - mTOR
KW  - rapamycin
KW  - regulatory T cells
KW  - suppression
KW  - Cell Movement
KW  - Cells, Cultured
KW  - Child
KW  - Diabetes Mellitus, Type 1
KW  - Diarrhea
KW  - Forkhead Transcription Factors
KW  - Gene Expression Regulation
KW  - Genetic Diseases, X-Linked
KW  - Glucocorticoid-Induced TNFR-Related Protein
KW  - Humans
KW  - Immune System Diseases
KW  - Immune Tolerance
KW  - Immunosuppressive Agents
KW  - Interleukins
KW  - Lymphocyte Activation
KW  - Male
KW  - Minor Histocompatibility Antigens
KW  - Mutation
KW  - Sirolimus
KW  - T-Lymphocytes, Regulatory
TI  - Treatment with rapamycin can restore regulatory T-cell function in IPEX patients.
TY  - research article
VL  - 145
ER  -