RT Journal Article
T1 Micafungin as antifungal prophylaxis in non-transplanted haemotological patients.
A1 Villaescusa, T
A1 Vázquez, L
A1 Bergua, J M
A1 García, J
A1 Romero, A
A1 Olave, M T
A1 García Belmonte, D
A1 Queipo de Llano, M P
A1 Grupo de Infecciones en pacientes hematológicos. Sociedad Andaluza de Hematología y Hemoterapia., 
K1 Aspergilllus
K1 echinocandins
K1 fungal
K1 prophylaxis
K1 toxicity
AB Fungal infections are a major cause of morbidity and mortality in the haematological patients. These infections are mainly due to Candida spp. and Aspergillus spp. Mortality by these infections is high, but rates have descended in the latest series due to better antifungal agents. Echinocan-dins are, in vitro, very active against Candida and Aspergillus spp. The objective of the study is to analyse the efficacy and safety of micafungin in the antifungal prophylaxis of haema-tological patients on chemotherapy. A multicentre, observational retrospective study was performed in 7 Haematology Depart-ments in Spain. Patients admitted to these departments with chemotherapy or immunosuppressive treatment, and who had received antifungal prophylaxis with micafungin between 1 January 2009 and 31 December 2014 were included. There were 5 cases of probable or proven fun-gal infection (4.8%) according to the 2008 EORTC criteria: 2 proven, 3 probable. The types of fungal infection were 3 as-pergillosis and 2 candidiasis. There were no drop-outs from the prophylaxis with micafungin due to toxicity. Micafungin is an antifungal agent which, used in prophylaxis, has demonstrated good efficacy and an excellent toxicity profile, making it an apparently interesting option in patients requiring antifungal prophylaxis during their hospitalisation episode.
YR 2019
FD 2019-12-23
LK http://hdl.handle.net/10668/14864
UL http://hdl.handle.net/10668/14864
LA en
DS RISalud
RD Apr 17, 2025