RT Journal Article
T1 Next-Generation Sequencing of PTGS Genes Reveals an Increased Frequency of Non-synonymous Variants Among Patients With NSAID-Induced Liver Injury.
A1 Lucena, María Isabel
A1 García-Martín, Elena
A1 Daly, Ann K
A1 Blanca, Miguel
A1 Andrade, Raúl J
A1 Agúndez, José A G
K1 COX1
K1 COX2
K1 PTGS1
K1 PTGS2
K1 drug-induced liver injury
K1 next generation sequencing
AB Purpose: The etiopathogenesis of drug-induced liver injury (DILI) is still far from being elucidated. This study aims to the study of genetic variations in DILI, related to the drug target, and specifically in the genes coding for the cyclooxygenase enzymes. Methods: By using Next-generation Sequencing we analyzed the genes coding for COX enzymes (PTGS1 and PTGS2) in 113 individuals, 13 of which were patients with DILI caused by COX-inhibitors. Results: The key findings of the study are the increased frequency, among DILI patients, of SNPs causing alterations in transcription factor binding sites and non-synonymous PTGS gene variants, as compared to control subjects. Moreover, the association with non-synonymous SNPs was exclusive of DILI patients with late-onset (50 days or more) Pc
SN 1664-8021
YR 2019
FD 2019-02-28
LK http://hdl.handle.net/10668/13713
UL http://hdl.handle.net/10668/13713
LA en
DS RISalud
RD Apr 6, 2025