TY - JOUR AU - Carmona, Rita AU - Cañete, Ana AU - Cano, Elena AU - Ariza, Laura AU - Rojas, Anabel AU - Muñoz-Chápuli, Ramon PY - 2016 DO - 10.7554/eLife.16009 UR - http://hdl.handle.net/10668/10457 T2 - eLife AB - Congenital diaphragmatic hernia (CDH) is a severe birth defect. Wt1-null mouse embryos develop CDH but the mechanisms regulated by WT1 are unknown. We have generated a murine model with conditional deletion of WT1 in the lateral plate mesoderm, using... LA - en KW - Gata4 KW - Wilms' tumor suppressor gene KW - congenital diaphragmatic hernia KW - developmental biology KW - epithelial-mesenchymal transition KW - human biology KW - medicine KW - mouse KW - stem cells KW - Animals KW - Diaphragm KW - Disease Models, Animal KW - Hernias, Diaphragmatic, Congenital KW - Mesoderm KW - Mice KW - Mice, Knockout KW - Repressor Proteins KW - Sequence Deletion KW - WT1 Proteins TI - Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice. TY - research article VL - 5 ER -