RT Journal Article
T1 Neutrophil Expression of T and B Immunomodulatory Molecules in HIV Infection
A1 Marquez-Coello, Mercedes
A1 Ruiz-Sanchez, Cristina
A1 Martin-Aspas, Andres
A1 Fernandez Gutierrez Del alamo, Clotilde
A1 Illanes-Alvarez, Francisco
A1 Cuesta-Sancho, Sara
A1 Giron-Gonzalez, Jose-Antonio
K1 HIV
K1 neutrophils
K1 BAFF
K1 APRIL
K1 bacterial translocation
K1 interleukins
K1 arginase-1
K1 PDL-1
K1 Immune activation
K1 Microbial translocation
K1 Cells
K1 Innate
K1 Il-10
AB ObjectiveEvaluate the expression of B and T cell immunomodulatory molecules in polymorphonuclear neutrophils (PMN) in HIV-infected patients. MethodsHIV load, bacterial translocation and neutrophils' expression of T [programmed death ligand, interleukin-10+, arginase 1+] and B [BAFF, APRIL] molecules were analyzed in different cohorts and time points: a control group of 25 healthy individuals and two groups of HIV-infected patients. Group 1 of patients included 35 untreated patients, studied at baseline and after antiretroviral therapy (ART). Group 2 was composed of 25 patients with undetectable viral load after a median of 101 months of ART prior to inclusion in the study. ResultsCompared with the control group, group 1 patients showed increased bacterial translocation and their PMN had a significantly higher expression of T and B-cell immunomodulatory molecules, both at baseline and after 12 months of ART. Group 2 patients showed reduced bacterial translocation levels when compared with group 1 patients after 12 months of treatment. PMN expression of B-cell modulators was similar between group 2 patients and healthy controls, although the expression of T-cell modulators remained increased. ConclusionIn HIV-infected patients, the expression of B-cell stimulatory and T-cell suppressive molecules by neutrophils was increased at baseline and after a limited time of therapy. After a prolonged period of ART, only PMNs expression of T-cell immunosuppressive molecules remained elevated.
PB Frontiers media sa
SN 1664-3224
YR 2021
FD 2021-12-17
LK https://hdl.handle.net/10668/25216
UL https://hdl.handle.net/10668/25216
LA en
DS RISalud
RD Apr 8, 2025