%0 Journal Article
%A Marquez-Coello, Mercedes
%A Ruiz-Sanchez, Cristina
%A Martin-Aspas, Andres
%A Fernandez Gutierrez Del alamo, Clotilde
%A Illanes-Alvarez, Francisco
%A Cuesta-Sancho, Sara
%A Giron-Gonzalez, Jose-Antonio
%T Neutrophil Expression of T and B Immunomodulatory Molecules in HIV Infection
%D 2021
%@ 1664-3224
%U https://hdl.handle.net/10668/25216
%X ObjectiveEvaluate the expression of B and T cell immunomodulatory molecules in polymorphonuclear neutrophils (PMN) in HIV-infected patients. MethodsHIV load, bacterial translocation and neutrophils' expression of T [programmed death ligand, interleukin-10+, arginase 1+] and B [BAFF, APRIL] molecules were analyzed in different cohorts and time points: a control group of 25 healthy individuals and two groups of HIV-infected patients. Group 1 of patients included 35 untreated patients, studied at baseline and after antiretroviral therapy (ART). Group 2 was composed of 25 patients with undetectable viral load after a median of 101 months of ART prior to inclusion in the study. ResultsCompared with the control group, group 1 patients showed increased bacterial translocation and their PMN had a significantly higher expression of T and B-cell immunomodulatory molecules, both at baseline and after 12 months of ART. Group 2 patients showed reduced bacterial translocation levels when compared with group 1 patients after 12 months of treatment. PMN expression of B-cell modulators was similar between group 2 patients and healthy controls, although the expression of T-cell modulators remained increased. ConclusionIn HIV-infected patients, the expression of B-cell stimulatory and T-cell suppressive molecules by neutrophils was increased at baseline and after a limited time of therapy. After a prolonged period of ART, only PMNs expression of T-cell immunosuppressive molecules remained elevated.
%K HIV
%K neutrophils
%K BAFF
%K APRIL
%K bacterial translocation
%K interleukins
%K arginase-1
%K PDL-1
%K Immune activation
%K Microbial translocation
%K Cells
%K Innate
%K Il-10
%~