RT Journal Article
T1 Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance.
A1 Yew Tan, Chong
A1 Virtue, Samuel
A1 Murfitt, Steven
A1 Robert, Lee D
A1 Phua, Yi Hui
A1 Dale, Martin
A1 Griffin, Julian L
A1 Tinahones, Francisco
A1 Scherer, Philipp E
A1 Vidal-Puig, Antonio
K1 Adiponectina
K1 Tejido adiposo
K1 Adiposidad
K1 Ácidos grasos, esenciales
K1 Ácidos grasos monoinsaturados
K1 Humanos
K1 Gato
K1 Grasa intra-abdominal
K1 Obesidad
K1 Grasa subcutánea
AB The non-essential fatty acids, C18:1n9, C16:0, C16:1n7, C18:0 and C18:1n7 account for over 75% of fatty acids in white adipose (WAT) triacylglycerol (TAG). The relative composition of these fatty acids (FA) is influenced by the desaturases, SCD1-4 and the elongase, ELOVL6. In knock-out models, loss of SCD1 or ELOVL6 results in reduced Δ9 desaturated and reduced 18-carbon non-essential FA respectively. Both Elovl6 KO and SCD1 KO mice exhibit improved insulin sensitivity. Here we describe the relationship between WAT TAG composition in obese mouse models and obese humans stratified for insulin resistance. In mouse models with increasing obesity and insulin resistance, there was an increase in scWAT Δ9 desaturated FAs (SCD ratio) and FAs with 18-carbons (Elovl6 ratio) in mice. Data from mouse models discordant for obesity and insulin resistance (AKT2 KO, Adiponectin aP2-transgenic), suggested that scWAT TAG Elovl6 ratio was associated with insulin sensitivity, whereas SCD1 ratio was associated with fat mass. In humans, a greater SCD1 and Elovl6 ratio was found in metabolically more harmful visceral adipose tissue when compared to subcutaneous adipose tissue.
PB Nature Publishing Group
YR 2015
FD 2015-12
LK http://hdl.handle.net/10668/2271
UL http://hdl.handle.net/10668/2271
LA en
NO Yew Tan C, Virtue S, Murfitt S, Robert LD, Phua YH, Dale M, et al. Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. Sci Rep. 2015; 5:18366
NO Journal Article;
DS RISalud
RD Apr 10, 2025