RT Journal Article
T1 Validation of self-reported perception of proximity to industrial facilities: MCC-Spain study.
A1 Castello, Adela
A1 Perez-Gomez, Beatriz
A1 Lora-Pablos, David
A1 Lope, Virginia
A1 Castaño-Vinyals, Gemma
A1 Vitelli-Storelli, Facundo
A1 Dierssen-Sotos, Trinidad
A1 Amiano, Pilar
A1 Guevara, Marcela
A1 Moreno, Víctor
A1 Lozano-Lorca, Macarena
A1 Tardon, Adonina
A1 Alguacil, Juan
A1 Hernandez-Garcia, Marta
A1 Marcos-Gragera, Rafael
A1 Chirlaque Lopez, Maria Dolores
A1 Ardanaz, Eva
A1 Ibarluzea, Jesus
A1 Gomez-Acebo, Ines
A1 Molina, Antonio J
A1 O'Callaghan-Gordo, Cristina
A1 Aragones, Nuria
A1 Kogevinas, Manolis
A1 Pollan, Marina
A1 Garcia-Perez, Javier
K1 AUC
K1 Case-control study
K1 Industrial pollution
K1 MCC-Spain
K1 Residential proximity
K1 Self-reported perception
K1 Sensitivity
K1 Specificity
AB Self-reported data about environmental exposures can lead to measurement error. To validate the self-reported perception of proximity to industrial facilities. MCC-Spain is a population-based multicase-control study of cancer in Spain that recruited incident cases of breast, colorectal, prostate, and stomach cancer. The participant's current residence and the location of the industries were geocoded, and the linear distance between them was calculated (gold standard). The epidemiological questionnaire included a question to determine whether the participants perceived the presence of any industry at ≤1 km from their residences. Sensitivity and specificity of individuals' perception of proximity to industries were estimated as measures of classification accuracy, and the area under the curve (AUC) and adjusted odds ratios (aORs) of misclassification were calculated as measures of discrimination. Analyses were performed for all cases and controls, and by tumor location, educational level, sex, industrial sector, and length of residence. Finally, aORs of cancer associated with real and self-reported distances were calculated to explore differences in the estimation of risk between these measures. Sensitivity of the questionnaire was limited (0.48) whereas specificity was excellent (0.89). AUC was sufficient (0.68). Participants with breast (aOR(95%CI) = 2.03 (1.67;2.46)), colorectal (aOR(95%CI) = 1.41 (1.20;1.64)) and stomach (aOR(95%CI) = 1.59 (1.20;2.10)) cancer showed higher risk of misclassification than controls. This risk was higher for lower educational levels (aOR15 years (95%CI) = 0.56 (0.36;0.85)). The use of self-reported proximity vs. real distance to industrial facilities biased the effect on cancer risk towards the nullity. Self-reported distance to industrial facilities can be a useful tool for hypothesis generation, but hypothesis-testing studies should use real distance to report valid conclusions. The sensitivity of the question might be improved with a more specific formulation.
PB Elsevier Ltd
YR 2019
FD 2019-11-06
LK http://hdl.handle.net/10668/14936
UL http://hdl.handle.net/10668/14936
LA en
NO Castelló A, Pérez-Gómez B, Lora-Pablos D, Lope V, Castaño-Vinyals G, Vitelli-Storelli F, et al. Validation of self-reported perception of proximity to industrial facilities: MCC-Spain study. Environ Int. 2020 Feb;135:105316.
NO The authors thank all those who took part in this study providing questionnaire data. This study was funded by: Scientific Foundation of the Spanish Association Against Cancer (Fundación Científica de la Asociación Española Contra el Cáncer (AECC) – EVP-1178/14), Spain's Health Research Fund (Fondo de Investigación Sanitaria – FIS 12/01416), the Spanish Ministry of Economy and Competitiveness (Carlos III Institute of Health; PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI14/01219 and Río Hortega CM13/00232), the Catalan Government 2009SGR1489 & 2014SGR756-F, the Fundación Marqués de Valdecilla ( API 10/09), the ICGC International Cancer Genome Consortium CLL, the Junta de Castilla y León (LE22A10-2), the Consejería de Salud of the Junta de Andalucía (PI-0571), the Conselleria de Sanitat of the Generalitat Valenciana (AP 061/10), the Recercaixa (2010ACUP 310), and the Regional Government of the Basque Country by European Commission grants FOOD-CT-2006-036224-HIWATE.
DS RISalud
RD Apr 7, 2025