TY - JOUR AU - Fernández-Fernández, Cristina AU - Callado, Luis F AU - Girón, Rocío AU - Sánchez, Eva AU - Erdozain, Amaia M AU - López-Moreno, José Antonio AU - Morales, Paula AU - Rodríguez de Fonseca, Fernando AU - Fernández-Ruiz, Javier AU - Goya, Pilar AU - Meana, J Javier AU - Martín, M Isabel AU - Jagerovic, Nadine PY - 2014 DO - 10.2147/DDDT.S55045 SN - 1177-8881 (Online) UR - http://hdl.handle.net/10668/1607 T2 - Drug design, development and therapy AB - Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared by coupling the molecular... LA - en KW - Fentanyl KW - Rimonabant KW - Cannabinoid KW - Opioid KW - Behavioral assays KW - Autopsia KW - Cannabinoides KW - Opioides KW - moduladores de los receptores de cannabinoides KW - Encéfalo KW - Interacciones farmacológicas KW - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Piperidines::Fentanyl KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Terpenes::Cannabinoids KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Central Nervous System Depressants::Narcotics KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Autopsy KW - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain KW - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Pharmacological Processes::Drug Interactions KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Cannabinoid Receptor Modulators TI - Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results. TY - research article ER -