RT Journal Article
T1 Evaluating the Association between Artificial Light-at-Night Exposure and Breast and Prostate Cancer Risk in Spain (MCC-Spain Study).
A1 Garcia-Saenz, Ariadna
A1 Sánchez de Miguel, Alejandro
A1 Espinosa, Ana
A1 Valentin, Antonia
A1 Aragonés, Núria
A1 Llorca, Javier
A1 Amiano, Pilar
A1 Martín Sánchez, Vicente
A1 Guevara, Marcela
A1 Capelo, Rocío
A1 Tardón, Adonina
A1 Peiró-Perez, Rosana
A1 Jiménez-Moleón, José Juan
A1 Roca-Barceló, Aina
A1 Pérez-Gómez, Beatriz
A1 Dierssen-Sotos, Trinidad
A1 Fernández-Villa, Tania
A1 Moreno-Iribas, Conchi
A1 Moreno, Victor
A1 García-Pérez, Javier
A1 Castaño-Vinyals, Gemma
A1 Pollán, Marina
A1 Aubé, Martin
A1 Kogevinas, Manolis
AB Night shift work, exposure to light at night (ALAN) and circadian disruption may increase the risk of hormone-dependent cancers. We evaluated the association of exposure to ALAN during sleeping time with breast and prostate cancer in a population based multicase-control study (MCC-Spain), among subjects who had never worked at night. We evaluated chronotype, a characteristic that may relate to adaptation to light at night. We enrolled 1,219 breast cancer cases, 1,385 female controls, 623 prostate cancer cases, and 879 male controls from 11 Spanish regions in 2008-2013. Indoor ALAN information was obtained through questionnaires. Outdoor ALAN was analyzed using images from the International Space Station (ISS) available for Barcelona and Madrid for 2012-2013, including data of remotely sensed upward light intensity and blue light spectrum information for each geocoded longest residence of each MCC-Spain subject. Among Barcelona and Madrid participants with information on both indoor and outdoor ALAN, exposure to outdoor ALAN in the blue light spectrum was associated with breast cancer [adjusted odds ratio (OR) for highest vs. lowest tertile, OR=1.47; 95% CI: 1.00, 2.17] and prostate cancer (OR=2.05; 95% CI: 1.38, 3.03). In contrast, those exposed to the highest versus lowest intensity of outdoor ALAN were more likely to be controls than cases, particularly for prostate cancer. Compared with those who reported sleeping in total darkness, men who slept in "quite illuminated" bedrooms had a higher risk of prostate cancer (OR=2.79; 95% CI: 1.55, 5.04), whereas women had a slightly lower risk of breast cancer (OR=0.77; 95% CI: 0.39, 1.51). Both prostate and breast cancer were associated with high estimated exposure to outdoor ALAN in the blue-enriched light spectrum. https://doi.org/10.1289/EHP1837.
YR 2018
FD 2018-04-23
LK http://hdl.handle.net/10668/12382
UL http://hdl.handle.net/10668/12382
LA en
DS RISalud
RD Apr 10, 2025