RT Journal Article
T1 Age-Related Loss in Bone Mineral Density of Rats Fed Lifelong on a Fish Oil-Based Diet Is Avoided by Coenzyme Q10 Addition
A1 Varela-López, Alfonso
A1 Ochoa, Julio J
A1 Llamas-Elvira, José M
A1 López-Frías, Magdalena
A1 Planells, Elena
A1 Ramirez-Tortosa, MCarmen
A1 Ramirez-Tortosa, Cesar L
A1 Giampieri, Francesca
A1 Battino, Maurizio
A1 Quiles, José L
K1 Antioxidants
K1 Dietary fat
K1 N-3 PUFA
K1 Oxidative stress
K1 Ubiquinone
K1 Antioxidantes
K1 Densidad ósea
K1 Dieta
K1 Suplementos dietéticos
K1 F2-Isoprostanos
K1 Acidos grasos omega-3
K1 Aceites de pescado
K1 Linfocitos b
K1 Osteocalcina
K1 Osteopontina
K1 Estrés oxidativo
K1 Hormona paratiroidea
K1 Ligando RANK
K1 Ubiquinona
K1 Armas
AB During aging, bone mass declines increasing osteoporosis and fracture risks. Oxidative stress has been related to this bone loss, making dietary compounds with antioxidant properties a promising weapon. Male Wistar rats were maintained for 6 or 24 months on diets with fish oil as unique fat source, supplemented or not with coenzyme Q10 (CoQ10), to evaluate the potential of adding this molecule to the n-3 polyunsaturated fatty acid (n-3 PUFA)-based diet for bone mineral density (BMD) preservation. BMD was evaluated in the femur. Serum osteocalcin, osteopontin, receptor activator of nuclear factor-κB ligand, ostroprotegerin, parathyroid hormone, urinary F₂-isoprostanes, and lymphocytes DNA strand breaks were also measured. BMD was lower in aged rats fed a diet without CoQ10 respect than their younger counterparts, whereas older animals receiving CoQ10 showed the highest BMD. F₂-isoprostanes and DNA strand breaks showed that oxidative stress was higher during aging. Supplementation with CoQ10 prevented oxidative damage to lipid and DNA, in young and old animals, respectively. Reduced oxidative stress associated to CoQ10 supplementation of this n-3 PUFA-rich diet might explain the higher BMD found in aged rats in this group of animals.
PB MDPI
YR 2017
FD 2017-02-22
LK http://hdl.handle.net/10668/2640
UL http://hdl.handle.net/10668/2640
LA en
NO Varela-López A, Ochoa JJ, Llamas-Elvira JM, López-Frías M, Planells E, Ramirez-Tortosa M et al. Age-Related Loss in Bone Mineral Density of Rats Fed Lifelong on a Fish Oil-Based Diet Is Avoided by Coenzyme Q10 Addition.Nutrients. 2017 Feb 22;9(2). pii: E176.
NO This work was supported by the Spanish Ministry of Education and Science (AGL2008-01057)and the Autonomous Government of Andalusia (AGR832).
DS RISalud
RD Apr 5, 2025