RT Journal Article
T1 Relationship between damage clustering and mortality in systemic lupus erythematosus in early and late stages of the disease: cluster analyses in a large cohort from the Spanish Society of Rheumatology Lupus Registry.
A1 Pego-Reigosa, José María
A1 Lois-Iglesias, Ana
A1 Rúa-Figueroa, Íñigo
A1 Galindo, María
A1 Calvo-Alén, Jaime
A1 de Uña-Álvarez, Jacobo
A1 Balboa-Barreiro, Vanessa
A1 Ibáñez Ruan, Jesús
A1 Olivé, Alejandro
A1 Rodríguez-Gómez, Manuel
A1 Fernández Nebro, Antonio
A1 Andrés, Mariano
A1 Erausquin, Celia
A1 Tomero, Eva
A1 Horcada Rubio, Loreto
A1 Uriarte Isacelaya, Esther
A1 Freire, Mercedes
A1 Montilla, Carlos
A1 Sánchez-Atrio, Ana I
A1 Santos-Soler, Gregorio
A1 Zea, Antonio
A1 Díez, Elvira
A1 Narváez, Javier
A1 Blanco-Alonso, Ricardo
A1 Silva-Fernández, Lucía
A1 Ruiz-Lucea, María Esther
A1 Fernández-Castro, Mónica
A1 Hernández-Beriain, José Ángel
A1 Gantes-Mora, Marian
A1 Hernández-Cruz, Blanca
A1 Pérez-Venegas, José
A1 Pecondón-Español, Ángela
A1 Marras Fernández-Cid, Carlos
A1 Ibáñez-Barcelo, Mónica
A1 Bonilla, Gema
A1 Torrente-Segarra, Vicenç
A1 Castellví, Iván
A1 Alegre, Juan José
A1 Calvet, Joan
A1 Marenco de la Fuente, José Luis
A1 Raya, Enrique
A1 Vázquez-Rodríguez, Tomás Ramón
A1 Quevedo-Vila, Víctor
A1 Muñoz-Fernández, Santiago
A1 Otón, Teresa
A1 Rahman, Anisur
A1 López-Longo, Francisco Javier
K1 RELESSER
K1 Spanish
K1 cluster analysis
K1 cohort
K1 mortality
K1 organ damage
K1 systemic lupus erythematosus
AB To identify patterns (clusters) of damage manifestations within a large cohort of SLE patients and evaluate the potential association of these clusters with a higher risk of mortality. This is a multicentre, descriptive, cross-sectional study of a cohort of 3656 SLE patients from the Spanish Society of Rheumatology Lupus Registry. Organ damage was ascertained using the Systemic Lupus International Collaborating Clinics Damage Index. Using cluster analysis, groups of patients with similar patterns of damage manifestations were identified. Then, overall clusters were compared as well as the subgroup of patients within every cluster with disease duration shorter than 5 years. Three damage clusters were identified. Cluster 1 (80.6% of patients) presented a lower amount of individuals with damage (23.2 vs 100% in clusters 2 and 3, P  In a large cohort of SLE patients, cardiovascular and musculoskeletal damage manifestations were the two dominant forms of damage to sort patients into clinically meaningful clusters. Both in early and late stages of the disease, there was a significant association of these clusters with an increased risk of mortality. Physicians should pay special attention to the early prevention of damage in these two systems.
YR 2016
FD 2016-03-27
LK http://hdl.handle.net/10668/9946
UL http://hdl.handle.net/10668/9946
LA en
DS RISalud
RD Apr 7, 2025