RT Journal Article
T1 Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity: Results from a Spanish multicenter registry (BIOCOVID-Spain study).
A1 García de Guadiana-Romualdo, Luis
A1 Morell-García, Daniel
A1 Favaloro, Emmanuel J
A1 Vílchez, Juan A
A1 Bauça, Josep M
A1 Alcaide Martín, María J
A1 Gutiérrez Garcia, Irene
A1 de la Hera Cagigal, Patricia
A1 Egea-Caparrós, José Manuel
A1 Pérez Sanmartín, Sonia
A1 Gutiérrez Revilla, José I
A1 Urrechaga, Eloísa
A1 Álamo, Jose M
A1 Hernando Holgado, Ana M
A1 Lorenzo-Lozano, María-Carmen
A1 Canalda Campás, Magdalena
A1 Juncos Tobarra, María A
A1 Morales-Indiano, Cristian
A1 Vírseda Chamorro, Isabel
A1 Pastor Murcia, Yolanda
A1 Sahuquillo Frías, Laura
A1 Altimira Queral, Laura
A1 Nuez-Zaragoza, Elisa
A1 Adell Ruiz de León, Juan
A1 Ruiz Ripa, Alicia
A1 Salas Gómez-Pablos, Paloma
A1 Cebreiros López, Iria
A1 Fernández Uriarte, Amaia
A1 Larruzea, Alex
A1 López Yepes, María L
A1 Sancho-Rodríguez, Natalia
A1 Zamorano Andrés, María C
A1 Pedregosa Díaz, José
A1 Sáenz, Luis
A1 Esparza Del Valle, Clara
A1 Baamonde Calzada, María C
A1 García Muñoz, Sara
A1 Vera, Marina
A1 Martín Torres, Esther
A1 Sánchez Fdez-Pacheco, Silvia
A1 Vicente Gutiérrez, Luis
A1 Jiménez Añón, Laura
A1 Pérez Martínez, Alfonso
A1 Pons Castillo, Aurelio
A1 González Tamayo, Ruth
A1 Férriz Vivancos, Jorge
A1 Rodríguez-Fraga, Olaia
A1 Díaz-Brito, Vicens
A1 Aguadero, Vicente
A1 García Arévalo, M G
A1 Arnaldos Carrillo, María
A1 González Morales, Mercedes
A1 Núñez Gárate, María
A1 Ruiz Iruela, Cristina
A1 Esteban Torrella, Patricia
A1 Vila Pérez, Martí
A1 Acevedo Alcaraz, Cristina
A1 Blázquez-Manzanera, Alfonso L
A1 Galán Ortega, Amparo
K1 COVID-19
K1 D-dimer
K1 Harmonization
K1 Mortality
K1 Prognosis
AB Coagulopathy is a key feature of COVID-19 and D-dimer has been reported as a predictor of severity. However, because D-dimer test results vary considerably among assays, resolving harmonization issues is fundamental to translate findings into clinical practice. In this retrospective multicenter study (BIOCOVID study), we aimed to analyze the value of harmonized D-dimer levels upon admission for the prediction of in-hospital mortality in COVID-19 patients. All-cause in-hospital mortality was defined as endpoint. For harmonization of D-dimer levels, we designed a model based on the transformation of method-specific regression lines to a reference regression line. The ability of D-dimer for prediction of death was explored by receiver operating characteristic curves analysis and the association with the endpoint by Cox regression analysis. Study population included 2663 patients. In-hospital mortality rate was 14.3%. Harmonized D-dimer upon admission yielded an area under the curve of 0.66, with an optimal cut-off value of 0.945 mg/L FEU. Patients with harmonized D-dimer ≥ 0.945 mg/L FEU had a higher mortality rate (22.4% vs. 9.2%; p 
YR 2021
FD 2021-07-16
LK http://hdl.handle.net/10668/18208
UL http://hdl.handle.net/10668/18208
LA en
DS RISalud
RD Apr 10, 2025