RT Journal Article
T1 Association of Blood Trihalomethane Concentrations with Risk of All-Cause and Cause-Specific Mortality in U.S. Adults: A Prospective Cohort Study.
A1 Sun, Yang
A1 Chen, Chen
A1 Mustieles, Vicente
A1 Wang, Liang
A1 Zhang, Yu
A1 Wang, Yi-Xin
A1 Messerlian, Carmen
K1 NHANES
K1 adults
K1 cancer
K1 mortality
K1 trihalomethanes
AB Water chlorination can lead to the formation of disinfection byproducts, including trihalomethanes (THMs). However, few epidemiologic studies have explored associations between THM exposure and mortality. This study included 6720 adults aged ≥40 years from the National Health and Nutrition Examination Survey 1999-2012 who had blood THM concentrations quantified. A higher risk of all-cause mortality was found across increasing quartile concentrations of blood chloroform (TCM) and total THMs (TTHMs; sum of all four THMs) (both p for trend = 0.02). Adults in the highest quartile of TCM and TTHM concentrations had hazard ratios (HRs) of 1.35 (95% confidence intervals: 1.05-1.74) and 1.37 (1.05-1.79), respectively, for all-cause mortality, compared with adults in the lowest quartile. When cause-specific mortality was evaluated, a positive relationship was found between blood bromodichloromethane (BDCM), dibromochloromethane (DBCM), bromoform (TBM), total brominated THMs (Br-THMs; sum of BDCM, DBCM, and TBM), and TTHM concentrations and risk of cancer death and between blood TCM and TTHMs and risk of other cause (noncancer/nonheart disease) mortality. Our findings suggest that higher exposure to Br-THMs was associated with increased cancer mortality risk, whereas TCM was associated with a greater risk of noncancer/nonheart disease mortality.
PB American Chemical Society
YR 2021
FD 2021-05-15
LK http://hdl.handle.net/10668/18026
UL http://hdl.handle.net/10668/18026
LA en
NO Sun Y, Chen C, Mustieles V, Wang L, Zhang Y, Wang YX, et al. Association of Blood Trihalomethane Concentrations with Risk of All-Cause and Cause-Specific Mortality in U.S. Adults: A Prospective Cohort Study. Environ Sci Technol. 2021 Jul 6;55(13):9043-9051.
DS RISalud
RD Apr 12, 2025