%0 Journal Article
%A O'Gorman, N
%A Wright, D
%A Poon, L C
%A Rolnik, D L
%A Syngelaki, A
%A Wright, A
%A Akolekar, R
%A Cicero, S
%A Janga, D
%A Jani, J
%A Molina, F S
%A de Paco Matallana, C
%A Papantoniou, N
%A Persico, N
%A Plasencia, W
%A Singh, M
%A Nicolaides, K H
%T Accuracy of competing-risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation.
%D 2017
%U http://hdl.handle.net/10668/10757
%X To examine the diagnostic accuracy of a previously developed model for prediction of pre-eclampsia (PE) by a combination of maternal factors and biomarkers at 11-13 weeks' gestation. This was a prospective first-trimester multicenter study of screening for PE in 8775 singleton pregnancies. A previously published algorithm was used for the calculation of patient-specific risk of PE in each individual. The detection rates (DRs) and false-positive rates (FPRs) for delivery with PE  In the study population, 239 (2.7%) cases developed PE, of which 17 (0.2%), 59 (0.7%) and 180 (2.1%) developed PE  Assessment of a combination of maternal factors and biomarkers at 11-13 weeks provides effective first-trimester screening for preterm PE. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
%K Bayes' theorem
%K first-trimester screening
%K mean arterial pressure
%K placental growth factor
%K pre-eclampsia
%K pregnancy-associated plasma protein-A
%K pyramid of pregnancy care
%K survival model
%K uterine artery Doppler
%~