RT Journal Article
T1 Insulin receptor substrate-1 expression is increased in circulating leukocytes of patients with acute coronary syndrome.
A1 Jiménez-Navarro, Manuel Francisco
A1 Bueno, Héctor
A1 Álvarez-Sala, Luis
A1 Rodríguez-Losada, Noéla
A1 Andrés, Vicente
A1 González-Navarro, Herminia
K1 Proteínas Sustrato del Receptor de Insulina
K1 Síndrome Coronario Agudo
K1 Síndrome X Metabólico
K1 Diabetes Mellitus
K1 Leucocitos Mononucleares
K1 Humanos
AB The mechanisms underlying the increased risk of cardiovascular disease associated with diabetes mellitus (DM) are not fully defined. Insulin resistance in human metabolic syndrome patients is associated with decreased expression of the insulin receptor substrate-2- (Irs2-) AKT2 axis in mononuclear leukocytes (MLs). Moreover, acute coronary syndrome (ACS) has been linked through genome-wide association studies to the 2q36-q37.3 locus, which contains the Irs1 gene. Here, we investigated the expression of insulin-signaling pathway genes in MLs from patients with DM, ACS, and ACS plus DM. Quantitative real-time PCR expression studies showed no differences in the mRNA levels of Irs2, Akt2, and Akt1 among all patients. However, Irs1 mRNA expression was significantly increased in patients with ACS-diabetics and nondiabetics-compared with diabetic patients without ACS (P < .02 and P < .005, resp.). The present study reveals for the first time an association between increased Irs1 mRNA levels in MLs of patients with ACS which is not related to DM.
PB Hindawi Publishing Corporation
SN 2090-5580
YR 2011
FD 2011
LK http://hdl.handle.net/10668/755
UL http://hdl.handle.net/10668/755
LA en
NO Jiménez-Navarro MF, Bueno H, Alvarez-Sala L, Rodríguez-Losada N, Andrés V, González-Navarro H. Insulin receptor substrate-1 expression is increased in circulating leukocytes of patients with acute coronary syndrome. ISRN Cardiol; 2011:740585
NO Journal Article;
DS RISalud
RD Apr 5, 2025